公开(公告)号：US20230151060A1

公开(公告)日：2023-05-18

申请号：US17773733

申请日：2020-11-05

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Mikimasa TANADA ,  Koji TAKANO ,  Atsushi MATSUO ,  Minoru TAMIYA ,  Aya CHIYODA ,  Toshiya ITO ,  Takeo IIDA

IPC分类号： C07K7/64 ,  C07D211/38 ,  C07C271/22 ,  C07D213/55 ,  C07D213/65 ,  C07D213/64 ,  C07D213/61 ,  C07D205/04 ,  C07C323/09 ,  C07F5/02 ,  C07D309/12 ,  C07C317/04 ,  C07D409/12 ,  C07D333/28 ,  C07D295/15

CPC分类号： C07K7/64 ,  C07D211/38 ,  C07C271/22 ,  C07D213/55 ,  C07D213/65 ,  C07D213/64 ,  C07D213/61 ,  C07D205/04 ,  C07C323/09 ,  C07F5/025 ,  C07D309/12 ,  C07C317/04 ,  C07D409/12 ,  C07D333/28 ,  C07D295/15 ,  A61K38/00

摘要： The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.

公开(公告)号：US20240158446A1

公开(公告)日：2024-05-16

申请号：US18289592

申请日：2022-05-06

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Hatsuo KAWADA ,  Koji TAKANO ,  Tomoya KOTAKE ,  Mirai KAGE ,  Satoshi HASHIMOTO ,  Minoru TAMIYA ,  Yuma WAKAMIYA ,  Ryuji HAYASHI ,  Yuya MORITA

IPC分类号： C07K7/64

CPC分类号： C07K7/64

摘要： Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue specific to KRAS.

公开(公告)号：US20240148821A1

公开(公告)日：2024-05-09

申请号：US18289451

申请日：2022-05-06

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Mikimasa TANADA ,  Koji TAKANO ,  Atsushi MATSUO ,  Minoru TAMIYA ,  Aya CHIYODA ,  Toshiya ITO ,  Takeo IIDA ,  Atsushi OHTA

IPC分类号： A61K38/12 ,  A61P35/02 ,  C07K7/64

CPC分类号： A61K38/12 ,  A61P35/02 ,  C07K7/64

摘要： The present inventors found cyclic peptide compounds that interact with Ras, and pharmaceutical compositions containing the cyclic peptide compounds or salts thereof, or solvates thereof.

公开(公告)号：US20230391818A1

公开(公告)日：2023-12-07

申请号：US18034424

申请日：2021-10-27

申请人： Chugai Seiyaku Kabushiki Kaisha

发明人： Kenichi NOMURA ,  Mirai KAGE ,  Minoru TAMIYA ,  Junichiro KANAZAWA

IPC分类号： C07K1/06 ,  C40B50/14

CPC分类号： C07K1/061 ,  C40B50/14

摘要： Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.