公开(公告)号：US20220089706A1

公开(公告)日：2022-03-24

申请号：US17423999

申请日：2019-01-22

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： NARENDRA R. VYAVAHARE ,  CHARLES D. RICE ,  NASIM NOSOUDI ,  SAKETH KARAMCHED ,  VAIDEESH PARASARAM

IPC: C07K16/18 ,  A61K47/68 ,  A61K49/00

Abstract: Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.