公开(公告)号：US09701681B2

公开(公告)日：2017-07-11

申请号：US14968208

申请日：2015-12-14

Applicant: CMG Pharmaceutical Co., Ltd. ,  HANDOK INC.

Inventor： Moonsoo Kim ,  Chaewoon Lee ,  Gilnam Lee ,  Cheol Hwan Yoon ,  Jeongbeob Seo ,  Je Hak Kim ,  MinWoo Lee ,  Hankyul Jeong ,  Hyang Choi ,  Myung Eun Jung ,  Kinam Lee ,  Hyun Jung Kim ,  Hye Kyoung Kim ,  Jae Il Lee ,  Misoon Kim ,  Soongyu Choi

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

Abstract: The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or

公开(公告)号：US20160168156A1

公开(公告)日：2016-06-16

申请号：US14968208

申请日：2015-12-14

Applicant: HANDOK INC. ,  CMG Pharmaceutical Co., Ltd.

Inventor： Moonsoo Kim ,  Chaewoon Lee ,  Gilnam Lee ,  Cheolhwan Yoon ,  Jeongbeob Seo ,  Jay Hak Kim ,  Minwoo Lee ,  Hankyul Jeong ,  Hyang Choi ,  Myung Eun Jung ,  Ki Nam Lee ,  Hyun Jung Kim ,  Hye Kyoung Kim ,  Jae Il Lee ,  MinWoo Lee ,  Misoon Kim ,  Soongyu Choi

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

Abstract: The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or

Abstract translation: 本公开提供了由式I表示的新型化合物或其药学上可接受的盐，溶剂合物，多晶型物，酯，互变异构体或前药。 该化合物可用作Trk的抑制剂，可用于治疗疼痛，癌症，炎症，神经变性疾病和某些感染性疾病。 在一些式I化合物中，Q是-CH = CR 3 C（O）NR 4 R 5，-C≡CC（O）NR 4 R 5或