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    3-Substituted-2,4-dihydro-benzodiazepines
    1.
    发明授权
    3-Substituted-2,4-dihydro-benzodiazepines 失效
    3-取代的-2,4-二氢苯并二氮杂

    公开(公告)号：US3905980A

    公开(公告)日：1975-09-16

    申请号：US51149074

    申请日：1974-10-02

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SCHNETTLER RICHARD A ,  SUH JOHN T

    IPC: C07D405/14 ,  C07D409/14 ,  C07D295/12 ,  C07D295/18

    CPC classification number: C07D405/14 ,  C07D409/14

    Abstract: The 3-substituted-2,4-dihydrobenzodiazepines and their pharmaceutically acceptable acid addition salts are central nervous system depressants. A compound disclosed is 3-(N-(N''-2thienoylpiperazino))-4,5-dihydro-1H-2,4-benzodiazepine hydroiodide.

    Abstract translation: 3-取代-2,4-二氢苯并二氮杂类及其药学上可接受的酸加成盐是中枢神经系统抑制剂。 公开的化合物是3- [N-（N'-2-噻吩酰基哌嗪基）] -4,5-二氢-1H-2,4-苯并二氮杂环丁烷氢碘酸盐。

    1-hydroxybenzo(b)quinolizine derivatives
    2.
    发明授权
    1-hydroxybenzo(b)quinolizine derivatives 失效
    1-羟基苯甲（B）喹唑啉衍生物

    公开(公告)号：US3661915A

    公开(公告)日：1972-05-09

    申请号：US3661915D

    申请日：1970-09-02

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SUH JOHN T ,  SCHNETTLER RICHARD A ,  DEER BROWN

    IPC: C07D455/04 ,  C07D39/12

    CPC classification number: C07D455/04

    Abstract: THE COMPOUNDS ARE 1-HYDROXYBENZO(B)QUINOLIZINES WHICH ARE USEFUL AS AGENTS TO CONTROL AGGRESSIVE ANTI-SOCIAL BEHAVIOR IN ANIMALS. THE COMPOUNDS ALSO MAY BE USED AS INTERMEDIATES IN THE PREPARATION OF PICKLING AGENTS, MOTHPROOFING AGENTS AND WOOD PRESERVATIVES. REPRESENTATIVE OF COMPOUNDS DISCLOSED ARE CIS-8,9-DIMETHOXY-1-HYDROXY1,3,4,6,11,11A-HEXAHYDRO - 2H - BENZO(B)QUINOLIZINE AND 8,9 - DIMETHOXY - 1 - HYDROXY - 1 - (3 - CHLOROBENZYL)1,3,4,6,11,11A-HEXAHYDRO-2H-BENZOZ(B)QUINOLIZINE.

    1-aminoalkylamino-benzo(b) quinolizines
    3.
    发明授权
    1-aminoalkylamino-benzo(b) quinolizines 失效
    1-氨基亚氨基 - 苯甲（B）喹啉

    公开(公告)号：US3578668A

    公开(公告)日：1971-05-11

    申请号：US3578668D

    申请日：1968-08-26

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SCHNETTLER RICHARD A ,  SUH JOHN T

    IPC: C07D455/04 ,  C07D39/12

    CPC classification number: C07D455/04

    Abstract: THE COMPOUNDS ARE 1-ALKYLAMINO-BENZO (B) QUINOLIZINES WHICH ARE USEFUL AS ANTIHYPERTENSIVE AGENTS AND CENTRAL NERVOUS SYSTEM STILULANTS AND AS INTERMEDIATES IN THE PREPARATION OF PICKING AGENTS, WOOD PRESERVATIVES AND MOTHPROOFING AGENTS. REPRESENTATIVE OF THE COMPOUNDS DISCLOSED ARE 1-(N-CYCLOHEXYLAMINOETHYL)-1,3,4,6,11,11AHEXAHYDRO-2H-BENZO (B) QUINOLIZINE AND 1-(DIMETHYLAMINOETHYL)-1,3,4,6,11,11,11A - HEXAHYDRO-2H-BENZO (B) QUINOLIZINE.

    L-3-hydroxymethyltyrosine and salts thereof
    4.
    发明授权
    L-3-hydroxymethyltyrosine and salts thereof 失效
    L-3-羟甲基酪氨酸及其盐

    公开(公告)号：US3904680A

    公开(公告)日：1975-09-09

    申请号：US31780072

    申请日：1972-12-22

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SUH JOHN T ,  SCHNETTLER RICHARD A

    IPC: A61K31/195 ,  C07C101/08

    CPC classification number: A61K31/195

    Abstract: The compound L-3-hydroxymethyltyrosine is a chelating agent for heavy metal ions and possesses antihypertensive activity. A process is disclosed for making optically pure L-3hydroxymethyltyrosine.

    Abstract translation: 化合物L-3-羟甲基酪氨酸是重金属离子的螯合剂，具有抗高血压活性。 公开了制备光学纯的L-3-羟甲基酪氨酸的方法。

    1 2-disubstituted benzo(b)quinolizines
    5.
    发明授权
    1 2-disubstituted benzo(b)quinolizines 失效
    1双取代苄基（B）喹啉

    公开(公告)号：US3655671A

    公开(公告)日：1972-04-11

    申请号：US3655671D

    申请日：1969-09-08

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SUH JOHN T ,  SCHNETTLER RICHARD A

    IPC: C07D455/04 ,  C07D498/14 ,  C07D39/00

    CPC classification number: C07D455/04

    Abstract: THE COMPOUNDS ARE 1,2-DISUBSTITUTED BENZOL(B)QUINOLIZINES WHICH ARE USEFUL AS ANTIHYPERTENSIVE AGENTS AND CENTRAL NERVOUS SYSTEM DEPRESSANTS. THE COMPOUNDS ARE ALSO USEFUL AS INTERMEDIATES IN THE PREPARATION OF PICKLING AGENTS, WOOD PERSERVATIVES AND MOTHPROFFING AGENTS. REPRESENTATIVE OF THE COMPOUNDS DISCLOSED ARE 1-HYDROXY-2N-METHYLANINO-1,3,4,6,11,11A - HEXAHYDRO - 2H - BENZO(B) QUINOLIZINE, AND 1-HYDROXY - 2 - N - (34 - DIMETHOXYBENZYL) - N - MEHTYLAMINO-1,3,4,6,11,11A-HEXAHYDRO--2HBENZO(B)QUINOLIZINE.

    13-substituted dibenzo(b g)quinolizines
    8.
    发明授权
    13-substituted dibenzo(b g)quinolizines 失效
    13取代二苯并（B）喹啉

    公开(公告)号：US3654284A

    公开(公告)日：1972-04-04

    申请号：US3654284D

    申请日：1969-11-03

    Applicant: COLGATE PALMOLIVE CO

    Inventor： SUH JOHN T ,  SCHNETTLER RICHARD A

    IPC: C07D455/03 ,  C07D39/12

    CPC classification number: C07D455/00

    Abstract: THE COMPOUNDS ARE 13-SUBSITUTED DIBENZO(B,G)QUINOLIZINES WHICH ARE USEFUL AS CENTRAL NERVOUS SYSTEM DEPRESSANTS AND AGENTS TO CONTROL AGGRESSIVE ANTISOCIAL BEHAVIOR IN ANIMALS. THE COMPOUNDS ALSO MAY BE USED AS INTERMEDIATES IN THE PREPARATION OF PICKLING AGENTS, MOTHPROOFING AGENTS AND WOOD PRESERVATIVES. REPRESENTATIVE OF COMPOUNDS DISCLOSED ARE 2,3-DIMETHOXY-13-HYDROXY13 - PHENYL - 5,7,12,13 - TETRAHYDRO-12AH-DIBENZO(B,G) QUINOLIZINE AND 2,3 - DIMETHOXY-13-HYDROXY-13-(3,4-DICHLOROPHENYL) - 2,7,12,13-TETRAHYDRO-12AH-DIBENZO(B,G) QUINOLIZINE.

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