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公开(公告)号:US20210223208A1
公开(公告)日:2021-07-22
申请号:US17058038
申请日:2019-05-27
发明人: Eduardo GIL SANTOS , Jose Jaime RUZ MARTINEZ , Oscar MALVAR VIDAL , Javier TAMAYO DE MIGUEL , Montserrat CALLEJA GOMEZ
IPC分类号: G01N29/02 , G01N29/036 , G01N29/24 , G01N29/34 , G02B6/293
摘要: The invention relates to a method and a system of mechanical resonance transduction for analyte analysis, suitable for its use in the identification of nanoparticles in the range between 1 MHz and 300 GHz, said method being characterized in that it comprises the following steps: a) disposing at least one analyte, possessing at least one mechanical vibration mode, on at least one mechanical resonator sensor that possesses at least one mechanical vibration mode, selectable in a plurality of working frequencies; b) monitoring the mechanical spectra of the of the analyte and the resonator sensor; c) varying the at least one mechanical vibration mode until at least one mechanical vibration mode reaches a strong coupling situation with the at least one mechanical vibration mode; d) collecting the frequency data at which the strong coupling occurs; e) estimating the resonance frequency and quality factor of the at least one mechanical vibration mode from the strong coupling frequency data obtained in step d).