公开(公告)号：US20180344843A1

公开(公告)日：2018-12-06

申请号：US16007685

申请日：2018-06-13

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Angelo FONTANA ,  Emiliano MANZO ,  Adele CUTIGNANO ,  Raffaele DE PALMA

IPC: A61K39/39 ,  C07H13/06

Abstract: The present invention relates to beta-glycolipid derivatives, their preparation and use as adjuvants in vaccines, as being suitable for being co-administered with antigens for vaccine prophylaxis and therapy.In certain embodiments, the beta-glycolipid derivatives of the invention also in their salified or complex form, are suitable for being co-administered with antigens for both therapeutic and prophylactic purposes or for vaccine prophylaxis and therapy.

公开(公告)号：US20150368680A1

公开(公告)日：2015-12-24

申请号：US14763364

申请日：2014-01-24

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Angelo FONTANA ,  Giuliana D'IPPOLITO ,  Laura DIPASQUALE

IPC: C12P7/56 ,  C12P7/54

CPC classification number: C12P7/56 ,  A61F5/055 ,  C07K14/79 ,  C12N9/0008 ,  C12N9/93 ,  C12P7/54 ,  C12Y102/07001

Abstract: A process is described for the use of biological components of anaerobic microorganisms, in particular cultures or enzymes of anaerobic bacteria from the order Thermotogales such as Thermotoga neapolitana, as agents for the capture and sequestration of carbon dioxide by reaction with an appropriate organic substrate. The products resulting from this reaction are organic molecules usable as raw materials in industries, such as food, biomedical, cosmetics and zootechnical industries.

Abstract translation: 描述了使用厌氧微生物的生物成分，特别是来自热氧化甘油（Thermotoga neapolitana）的厌氧细菌的培养物或酶的生物成分作为通过与合适的有机底物反应捕获和螯合二氧化碳的试剂的方法。 该反应产生的产物是可用作食品，生物医药，化妆品和动物工业等行业的原料的有机分子。

公开(公告)号：US20160151483A1

公开(公告)日：2016-06-02

申请号：US14896789

申请日：2014-06-10

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Angelo FONTANA ,  Emiliano MANZO ,  Adele CUTIGNANO ,  Raffaele DE PALMA

IPC: A61K39/39 ,  C07H13/06

CPC classification number: A61K39/39 ,  C07H13/06

Abstract: The present invention relates to beta-glycolipid derivatives, their preparation and use as adjuvants in vaccines, as being suitable for being co-administered with antigens for vaccine prophylaxis and therapy. In certain embodiments, the beta-glycol-lipid derivatives of the invention also in their salified or complex form, are suitable for being co-administered with antigens for both therapeutic and prophylactic purposes or for vaccine prophylaxis and therapy.

Abstract translation: 本发明涉及β-糖脂衍生物，它们在疫苗中作为佐剂的制备和用途，适用于与用于疫苗预防和治疗的抗原共同施用。 在某些实施方案中，本发明的β-二醇 - 脂质衍生物也以其盐化或复合形式适合于与治疗和预防目的的抗原共同施用或用于疫苗预防和治疗。