公开(公告)号：US20230227832A1

公开(公告)日：2023-07-20

申请号：US18002213

申请日：2021-06-17

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Vittorio DE FRANCISCIS ,  Gerolama CONDORELLI ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Cristina QUINTAVALLE ,  Francesco INGENITO

IPC: C12N15/115 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12Q1/6886 ,  C12N2310/16

Abstract: The present invention relates to a nucleotide aptamer or a variant thereof, or a functional fragment thereof, the medical or diagnostic use thereof, the related pharmaceutical composition and a method for selecting a nucleotide aptamer which specifically binds to exosomes isolated from target cells. The present invention further relates to a kit and nucleic acid coding for the aptamer.

公开(公告)号：US20220356475A1

公开(公告)日：2022-11-10

申请号：US17640647

申请日：2020-08-31

Applicant: UNIVERSITA' DEGLI STUDI DI TORINO ,  CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Daniela TAVERNA ,  Lorena QUIRICO ,  Francesca ORSO ,  Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO

IPC: C12N15/115 ,  A61K9/00 ,  A61P35/00

Abstract: A chimeric complex comprising a microRNA in combination with an aptamer for AXL receptor tyrosine kinase is provided. Use of the chimeric complex for targeted treatment of a tumor disease, in particular in a therapy affecting onset and/or progression of tumor metastasis is also provided.