公开(公告)号：US20150275215A1

公开(公告)日：2015-10-01

申请号：US14433386

申请日：2013-10-04

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Laura Cerchia ,  Gerolama Condorelli ,  Vittorio De Franciscis

IPC: C12N15/115

CPC classification number: C12N15/115 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3533

Abstract: Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFRβ and are therefore useful in the diagnosis and/or therapy of PDGFRβ-associated and hyperproliferative-associated diseases, such as cancer and primary tumour metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2′-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.

Abstract translation: 提供了能够中和PDGFR和bgr的核酸酶抗性的RNA适体; 因此可用于诊断和/或治疗PDGFR和相关和过度增殖相关疾病，如癌症和原发性肿瘤转移。 本文提供的RNA适体包括修饰的合成RNA序列，其中至少一个嘧啶残基被修饰成2'-氟嘧啶。 还提供了包含RNA适体的药物组合物和诊断试剂盒。

公开(公告)号：US20220411799A1

公开(公告)日：2022-12-29

申请号：US17772769

申请日：2020-10-28

Applicant: National University of Singapore ,  Beth Israel Deaconess Medical Center, Inc. ,  Consiglio Nazionale Delle Ricerche

Inventor： Daniel Geoffrey Tenen ,  Carla Lucia Esposito ,  Annalisa Di Ruscio ,  Vittorio De Franciscis ,  Alexander K. Ebralidze

IPC: C12N15/115 ,  C12Q1/6811 ,  C12N15/10

Abstract: An aptamer, capable of inhibiting DNA methyltransferase 1 (DNMT1) for use in therapy of diseases characterised by aberrant DNA methylation, e.g. cancer. Method for identifying inhibitors of DNA methyltransferase. An aptamer, capable of inhibiting DNA methyltransferase 1 (DNMT1) for use in therapy of diseases characterised by aberrant DNA methylation, e.g. cancer. SELEX method for identifying aptamers of DNA methyltransferase optionally using 2-fluoro-pyrimindine nucleotide derivatives.

公开(公告)号：US09234202B2

公开(公告)日：2016-01-12

申请号：US14433386

申请日：2013-10-04

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Laura Cerchia ,  Gerolama Condorelli ,  Vittorio De Franciscis

IPC: C12N15/115

CPC classification number: C12N15/115 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/344 ,  C12N2310/3533

Abstract: Nuclease-resistant RNA aptamers are provided which are capable of neutralizing PDGFRβ and are therefore useful in the diagnosis and/or therapy of PDGFRβ-associated and hyperproliferative-associated diseases, such as cancer and primary tumor metastasis. RNA aptamers provided herein include a modified synthetic RNA sequence wherein at least one pyrimidine residue is modified to 2′-fluoropyrimidine. Pharmaceutical compositions and diagnostic kits comprising RNA aptamers are also provided.

Abstract translation: 提供了能够中和PDGFR和bgr的核酸酶抗性的RNA适体; 因此可用于诊断和/或治疗PDGFR和相关和过度增殖相关疾病，如癌症和原发性肿瘤转移。 本文提供的RNA适体包括修饰的合成RNA序列，其中至少一个嘧啶残基被修饰成2'-氟嘧啶。 还提供了包含RNA适体的药物组合物和诊断试剂盒。

公开(公告)号：US12077760B2

公开(公告)日：2024-09-03

申请号：US17413550

申请日：2019-12-16

Applicant: Board of Regents, The University of Texas System ,  Consiglio Nazionale delle Ricerche

Inventor： Gabriel Lopez-Berestein ,  Paola Amero ,  Cristian Rodriguez-Aguayo ,  Rahul Mitra ,  Anil K. Sood ,  Vittorio De Franciscis ,  David Volk ,  Lokesh Ganesh L. Rao

IPC: C12N15/115 ,  A61K31/337 ,  A61K33/243 ,  A61P35/00

CPC classification number: C12N15/115 ,  A61K31/337 ,  A61K33/243 ,  A61P35/00 ,  C12N2310/16 ,  C12N2310/313 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32

Abstract: Provided herein are DNA aptamers targeting AXL receptor kinase. The DNA aptamers may comprise a thiophosphate backbone and be chemically modified. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer.