公开(公告)号：US20210147395A1

公开(公告)日：2021-05-20

申请号：US17045028

申请日：2019-04-02

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  MOLIPHARMA S.R.L.

Inventor： Maria Cristina DE ROSA ,  Davide PIROLLI ,  Giovanni SCAMBIA ,  Daniela GALLO ,  Marco PETRILLO ,  Marta DE DONATO ,  Benedetta RIGHINO

IPC: C07D405/06 ,  C07D471/04

Abstract: The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.