公开(公告)号：US20040072757A1

公开(公告)日：2004-04-15

申请号：US10712332

申请日：2003-11-13

申请人： COR Therapeutics, Inc.

发明人： David L. Wolf ,  Uma Sinha

IPC分类号： A61K038/37

CPC分类号： C12N9/6464 ,  A61K38/00 ,  C07K14/745 ,  C12N9/6432 ,  C12N9/647 ,  C12Y304/21006 ,  C12Y304/21069

摘要： Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.

摘要翻译： 短暂失活的血液因子的类似物可用于治疗以血栓形成为特征的疾病。 此外，在血清中产生活性血因子但具有延长半衰期的活化血液因子的修饰形式可用于治疗嗜血性病症。 血液因子的这些修饰形式可以是在体内缓慢脱酰基化的酰化形式。