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公开(公告)号：US10064878B2
公开(公告)日：2018-09-04
申请号：US15369296
申请日：2016-12-05
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
摘要： The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
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公开(公告)号：US10052286B2
公开(公告)日：2018-08-21
申请号：US15646585
申请日：2017-07-11
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
CPC分类号： A61K9/2081 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2045 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/28 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/58 , H05K999/99
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
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公开(公告)号：US10143698B2
公开(公告)日：2018-12-04
申请号：US15646330
申请日：2017-07-11
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
摘要： The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
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公开(公告)号：US09532954B2
公开(公告)日：2017-01-03
申请号：US14308305
申请日：2014-06-18
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
CPC分类号： A61K31/58 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/28 , A61K9/2806 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866
摘要： The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
摘要翻译： 本发明涉及包含分散在至少一种亲水化合物或基质中的颗粒的片剂。 颗粒含有活性剂，至少一种两亲化合物和至少一种亲脂性化合物。 片剂可以包括耐胃膜包衣。
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公开(公告)号：US10105374B2
公开(公告)日：2018-10-23
申请号：US15646538
申请日：2017-07-11
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
摘要： The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
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公开(公告)号：US09592203B2
公开(公告)日：2017-03-14
申请号：US15202962
申请日：2016-07-06
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
CPC分类号： A61K9/2081 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2045 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/28 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/58 , H05K999/99
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
摘要翻译： 含有一种或多种在三组分基质结构中交联的活性成分的受控释放和掩味组合物，即由连续的两亲性，亲脂性或惰性基质形成的结构，最后在亲水基质中漂白或分散。 使用多个用于控制活性成分溶解的系统调节活性成分在水和/或生物流体中的溶解速率，从而控制胃肠道中的释放动力学。
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公开(公告)号：US10660858B2
公开(公告)日：2020-05-26
申请号：US16263223
申请日：2019-01-31
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
IPC分类号： A61K9/28 , A61K9/20 , A61K31/58 , A61K9/00 , A61K9/24 , A61K31/155 , A61K31/18 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/205 , A61K31/221 , A61K31/606 , A61K9/16
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
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公开(公告)号：US09737489B2
公开(公告)日：2017-08-22
申请号：US15368911
申请日：2016-12-05
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
CPC分类号： A61K9/2081 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2045 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/28 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/58 , H05K999/99
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
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公开(公告)号：US09192581B2
公开(公告)日：2015-11-24
申请号：US14491363
申请日：2014-09-19
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
CPC分类号： A61K9/2081 , A61K9/0053 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2045 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/28 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K31/58 , H05K999/99
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
摘要翻译： 含有一种或多种在三组分基质结构中交联的活性成分的受控释放和掩味组合物，即由连续的两亲性，亲脂性或惰性基质形成的结构，最后在亲水基质中漂白或分散。 使用多个用于控制活性成分溶解的系统调节活性成分在水和/或生物流体中的溶解速率，从而控制胃肠道中的释放动力学。
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公开(公告)号：US10307375B2
公开(公告)日：2019-06-04
申请号：US16139793
申请日：2018-09-24
发明人： Roberto Villa , Massimo Pedrani , Mauro Ajani , Lorenzo Fossati
IPC分类号： A61K9/28 , A61K9/20 , A61K31/58 , A61K9/00 , A61K9/24 , A61K31/155 , A61K31/18 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/205 , A61K31/221 , A61K31/606 , A61K9/16
摘要： Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
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