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公开(公告)号：US09957329B2
公开(公告)日：2018-05-01
申请号：US14374300
申请日：2013-01-31
申请人： CSL BEHRING GMBH , CSL LTD. , JULIUS-MAXIMILIANS-UNIVERSITAET-WUERZBURG , WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
IPC分类号： A61K38/16 , A61K38/17 , A61K38/48 , A61K39/395 , C07K16/40 , A61K38/06 , A61K38/55 , A61K38/57 , C07K14/81 , C07K16/36 , A61K39/00
CPC分类号： C07K16/40 , A61K38/06 , A61K38/16 , A61K38/1774 , A61K38/48 , A61K38/4846 , A61K38/55 , A61K38/556 , A61K38/57 , A61K39/395 , A61K2039/505 , C07K14/811 , C07K16/36 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： This application relates to neurological inflammatory diseases, such as multiple sclerosis, and to methods of administering a Factor XII inhibitor to prevent, treat, or otherwise ameliorate the effects of a neurological inflammatory disease, such as multiple sclerosis. Agents and pharmaceutical compositions comprising agents which inhibit the activity of FXII are also provided.
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2.发明申请Factor XII Inhibitors for the Treatment of Neurological Inflammatory Disorders 有权因子XII抑制剂治疗神经性炎症性疾病公开(公告)号：US20140378653A1
公开(公告)日：2014-12-25
申请号：US14374300
申请日：2013-01-31
申请人： CSL BEHRING GMBH , CSL LTD. , JULIUS-MAXIMILIANS-UNIVERSITAET-WUERZBURG , WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
CPC分类号： C07K16/40 , A61K38/06 , A61K38/16 , A61K38/1774 , A61K38/48 , A61K38/4846 , A61K38/55 , A61K38/556 , A61K38/57 , A61K39/395 , A61K2039/505 , C07K14/811 , C07K16/36 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： This application relates to neurological inflammatory diseases, such as multiple sclerosis, and to methods of administering a Factor XII inhibitor to prevent, treat, or otherwise ameliorate the effects of a neurological inflammatory disease, such as multiple sclerosis. Agents and pharmaceutical compositions comprising agents which inhibit the activity of FXII are also provided.
摘要翻译： 本申请涉及神经炎症性疾病，例如多发性硬化症，以及施用因子XII抑制剂以预防，治疗或以其它方式改善神经性炎性疾病如多发性硬化症的作用的方法。 还提供了包含抑制FXII活性的试剂和药物组合物。
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公开(公告)号：US20180134806A1
公开(公告)日：2018-05-17
申请号：US15822559
申请日：2017-11-27
申请人： CSL Behring GmbH , CSL Ltd
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
摘要： The invention relates to inhibitory anti-factor XII/FXIla antibodies and methods of their use.
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公开(公告)号：US20170121423A1
公开(公告)日：2017-05-04
申请号：US15343401
申请日：2016-11-04
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
IPC分类号： C07K16/36
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/36 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21038
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US11345759B2
公开(公告)日：2022-05-31
申请号：US16674131
申请日：2019-11-05
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US09856326B2
公开(公告)日：2018-01-02
申请号：US15343447
申请日：2016-11-04
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
IPC分类号： A61K39/395 , C07K16/40 , A61K39/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/36 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21038
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US20200062863A1
公开(公告)日：2020-02-27
申请号：US16674131
申请日：2019-11-05
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US10513560B2
公开(公告)日：2019-12-24
申请号：US15822559
申请日：2017-11-27
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
IPC分类号： A61K39/395 , C07K16/40 , C07K16/36 , A61K39/00
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US09856325B2
公开(公告)日：2018-01-02
申请号：US15343401
申请日：2016-11-04
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/36 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21038
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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公开(公告)号：US20170137536A1
公开(公告)日：2017-05-18
申请号：US15343447
申请日：2016-11-04
申请人： CSL Behring GmbH , CSL Ltd.
发明人： Con Panousis , Veronika Rayzman , Andrew Nash , Michael Wilson , Stefan Schmidbauer , Marc Nolte
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/36 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21038
摘要： The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.
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