公开(公告)号：US20240000908A1

公开(公告)日：2024-01-04

申请号：US18253485

申请日：2021-11-18

申请人： CSL Behring GmbH

发明人： John Roberts ,  Marc Uknis ,  Christine Voigt

IPC分类号： A61K38/57 ,  A61P37/06

CPC分类号： A61K38/57 ,  A61P37/06

摘要： The invention relates to methods of treating antibody-mediated rejection in a subject comprising administering C1-INH to the subject according to a schedule with the following steps: (a) intravenously administering one or more iv-doses of C1-INH, (b) subcutaneously administering at least 10 sc-doses of C1-INH over several weeks, wherein each week at least one sc-dose is administered. The invention further relates to a method of treating antibody-mediated rejection in a transplant recipient comprising subcutaneously administering C1-INH over at least 10 weeks, wherein each week at least one sc-dose is administered.