公开(公告)号：US20230002508A1

公开(公告)日：2023-01-05

申请号：US17781995

申请日：2020-12-03

申请人： CSL INNOVATION PTY LTD

发明人： lngo PRAGST ,  Dipti PAWASKAR ,  Theresa YURASZECK ,  Ying ZHANG

IPC分类号： C07K16/36 ,  A61P7/00

摘要： The present disclosure relates to methods of treating or preventing hereditary angioedema (HAE) in a subject in need thereof by subcutaneously administering to the subject an effective amount an anti-FXII antibody comprising (i) a VH comprising a CDRH1 comprising a sequence set forth in SEQ ID NO:1; a CDRH2 comprising a sequence set forth in SEQ ID NO:2; and a CDRH3 comprising a sequence set forth in SEQ ID NO:3; and (ii) a VL comprising a CDRL1 comprising a sequence set forth in SEQ ID NO:4; a CDRL2 comprising a sequence set forth in SEQ ID NO:5; and a CDRL3 comprising a sequence set forth in SEQ ID NO:6.