公开(公告)号：US20220220209A1

公开(公告)日：2022-07-14

申请号：US17299590

申请日：2019-12-04

申请人： CSL Innovation Pty Ltd

发明人： Karen Lisa INGUANTI ,  Jolanta AIREY ,  Jagdev SIDHU ,  Michael TORTORICI ,  Theresa YURASZECK

IPC分类号： C07K16/28 ,  A61P17/10 ,  A61P17/06

摘要： The present disclosure relates to a method for reducing circulating neutrophils in a subject without causing sustained grade 3 or grade 4 neutropenia. The present disclosure also relates to methods for treating neutrophilic conditions with an antibody that inhibit G-CSF signalling. In particular, the present disclosure relates to methods of 5 treating neutrophilic dermatoses, such as hidradenitis suppurativa (HS) and palmoplantar pustulosis (PPP).