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公开(公告)号：US12071484B2
公开(公告)日：2024-08-27
申请号：US16924282
申请日：2020-07-09
Applicant: CSL LIMITED
Inventor： Andrew Donald Nash , Arna Elizabeth Andrews , Manuel Baca , Kirsten Mae Edwards , Matthew Philip Hardy , Con Panousis , Felicity Meredith Dunlop
CPC classification number: C07K16/2866 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
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公开(公告)号：US20170369579A1
公开(公告)日：2017-12-28
申请号：US15697086
申请日：2017-09-06
Applicant: CSL Limited
Inventor： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
Abstract: High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
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公开(公告)号：US20170226214A1
公开(公告)日：2017-08-10
申请号：US15490318
申请日：2017-04-18
Applicant: CSL LIMITED
Inventor： Andrew Donald Nash , Arna Elizabeth Andrews , Manuel Baca , Kirsten Mae Edwards , Matthew Philip Hardy , Con Panousis , Felicity Meredith Dunlop
IPC: C07K16/28
CPC classification number: C07K16/2866 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
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4.发明申请HIGH AFFINITY ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR ALPHA 1 有权白细胞介素-13受体ALPHA 1的高亲和力抗体拮抗剂公开(公告)号：US20140056915A1
公开(公告)日：2014-02-27
申请号：US14052791
申请日：2013-10-14
Applicant: CSL Limited
Inventor： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
IPC: C07K16/28
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
Abstract: High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
Abstract translation: 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。
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公开(公告)号：US20250051462A1
公开(公告)日：2025-02-13
申请号：US18774057
申请日：2024-07-16
Applicant: CSL LIMITED
Inventor： Andrew Donald Nash , Arna Elizabeth Andrews , Manuel Baca , Kirsten Mae Edwards , Matthew Philip Hardy , Con Panousis , Felicity Meredith Dunlop
Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
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Patent Agency Ranking
公开(公告)号：US20210009701A1
公开(公告)日：2021-01-14
申请号：US16924282
申请日：2020-07-09
Applicant: CSL LIMITED
Inventor： Andrew Donald Nash , Arna Elizabeth Andrews , Manuel Baca , Kirsten Mae Edwards , Matthew Philip Hardy , Con Panousis , Felicity Meredith Dunlop
IPC: C07K16/28
Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
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公开(公告)号：US09777062B2
公开(公告)日：2017-10-03
申请号：US15160166
申请日：2016-05-20
Applicant: CSL Limited
Inventor： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
Abstract: High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
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8.发明申请HIGH AFFINITY ANTIBODY ANTAGONISTS OF INTERLEUKIN-13 RECEPTOR ALPHA 1 有权白细胞介素-13受体ALPHA 1的高亲和力抗体拮抗剂公开(公告)号：US20160362497A1
公开(公告)日：2016-12-15
申请号：US15160166
申请日：2016-05-20
Applicant: CSL Limited
Inventor： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
CPC classification number: C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
Abstract: High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13α1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
Abstract translation: 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13α1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。
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公开(公告)号：US20190055313A1
公开(公告)日：2019-02-21
申请号：US16111323
申请日：2018-08-24
Applicant: CSL LIMITED
Inventor： Andrew Donald Nash , Arna Elizabeth Andrews , Manuel Baca , Kirsten Mae Edwards , Matthew Philip Hardy , Con Panousis , Felicity Meredith Dunlop
Abstract: The present disclosure provides proteins comprising antigen binding domains of antibodies that bind to human granulocyte-colony stimulating factor receptor.
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10.发明授权Method of treating pulmonary disease by administering an antibody to G-CSF 有权通过给予G-CSF的抗体来治疗肺部疾病的方法公开(公告)号：US09376682B2
公开(公告)日：2016-06-28
申请号：US14042931
申请日：2013-10-01
Applicant: CSL LIMITED
Inventor： David Eric Crump , Andrew Donald Nash
IPC: A61K39/395 , C12N15/113 , A01K67/027 , C07K14/535 , C07K16/24 , A61K38/17 , A61K45/06 , C07K16/22 , C07K16/28 , A61K48/00 , A61K39/00
CPC classification number: C12N15/1138 , A01K67/027 , A01K2227/105 , A01K2267/0368 , A61K38/1793 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/535 , C07K16/22 , C07K16/243 , C07K16/2863 , C07K2317/73 , C12N15/1136
Abstract: The present invention relates generally to a method for treating or preventing or otherwise ameliorating the effects of pulmonary diseases characterized by or associated with infiltration of neutrophils and complications arising therefrom. The present invention further provides agents and pharmaceutical compositions comprising agents which inhibit the activity of G-CSF or its receptor, interfere with G-CSF signaling and/or which down-regulate expression of G-CSF or its receptor.
Abstract translation: 本发明一般涉及用于治疗或预防或以其他方式改善特征为嗜中性粒细胞浸润或与之相关的肺部疾病的影响的方法及其引起的并发症。 本发明还提供包含抑制G-CSF或其受体的活性，干扰G-CSF信号传导和/或下调G-CSF或其受体表达的试剂和药物组合物。
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