公开(公告)号：US10894834B2

公开(公告)日：2021-01-19

申请号：US15779252

申请日：2016-11-25

Applicant: CSL Limited

Inventor： Catherine Owczarek ,  Kosta Panousis ,  Nicholas Wilson ,  Matthew Hardy ,  Kirsten Edwards ,  Veronika Rayzman

IPC: C07K16/28 ,  A61P37/06 ,  G01N33/68 ,  A61K39/00

Abstract: The present disclosure provides a CD131-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds to or specifically binds to CD131 and neutralizes signaling by interleukin (IL) 3, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF), and uses thereof.

公开(公告)号：US11840573B2

公开(公告)日：2023-12-12

申请号：US16953499

申请日：2020-11-20

Applicant: CSL LIMITED

Inventor： Catherine Owczarek ,  Con Panousis ,  Nicholas Wilson ,  Matthew Hardy ,  Kirsten Edwards ,  Veronika Rayzman

IPC: C07K16/28 ,  A61P37/06 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61P37/06 ,  G01N33/68 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/543 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70596

Abstract: The present disclosure provides a CD131-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain binds to or specifically binds to CD131 and neutralizes signaling by interleukin (IL) 3, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF), and uses thereof.