公开(公告)号：US20240376119A1

公开(公告)日：2024-11-14

申请号：US18516710

申请日：2022-05-20

Applicant: CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.

Inventor： Guorui MI ,  Chuanwu ZHAO ,  Qian GUO ,  Jianan ZHANG ,  Chunna LI ,  Wenli WEI ,  Yanxia XU

IPC: C07D491/107 ,  A61K31/497 ,  A61K31/506 ,  A61K31/519 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D519/00

Abstract: Provided in the present invention are a class of compounds as represented by formula (I), or a prodrug, a tautomer, a stereoisomer, a solvate, and an isotopic derivative thereof, or a pharmaceutically acceptable salt thereof. The compound has an SHP2 kinase inhibitory effect and can be used for treating and/or preventing diseases, disorders, and conditions mediated by SHP2 activity, such as tumors, cancers, cancer metastasis, cardiovascular diseases, immune disorders, visual disorders, etc.