Patent search ap:("California Institute of Technology") AND inv:"Matthew Porteus" Page 1

1.

发明授权
Use of chimeric nucleases to stimulate gene targeting 有权

公开(公告)号：US10006053B2

公开(公告)日：2018-06-26

申请号：US15259848

申请日：2016-09-08

Applicant: California Institute of Technology

Inventor： David Baltimore , Matthew Porteus

IPC: C12N15/90

CPC classification number: C12N15/907 , A61K48/00 , C07K2319/00 , C07K2319/09 , C07K2319/43 , C07K2319/81 , C12N9/22 , C12N2800/80 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/203

Abstract: Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.

2.

发明申请
USE OF CHIMERIC NUCLEASES TO STIMULATE GENE TARGETING 有权

公开(公告)号：US20170114368A1

公开(公告)日：2017-04-27

申请号：US15259848

申请日：2016-09-08

Applicant: California Institute of Technology

Inventor： David Baltimore , Matthew Porteus

IPC: C12N15/90

CPC classification number: C12N15/907 , A61K48/00 , C07K2319/00 , C07K2319/09 , C07K2319/43 , C07K2319/81 , C12N9/22 , C12N2800/80 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/203

Abstract: Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.

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