公开(公告)号：US20210052695A1

公开(公告)日：2021-02-25

申请号：US16964695

申请日：2019-01-25

Applicant: Cambridge Enterprise Limited

Inventor： Louise Helen Boyle ,  Andreas Heinrich Neerincx ,  Florin Tudor ILCA

IPC: A61K38/16 ,  C12N5/0783 ,  C12N5/0784 ,  C07K14/74

Abstract: This invention relates to peptide-exchange proteins comprising the luminal domain of TAP-binding protein-related (TAPBPR), which functions as a MHC class I peptide-exchange catalyst when presented to mammalian cells either as a soluble extracellular protein or as a membrane bound cell surface protein. This may be useful in modulating immune responses, including for example loading immunogenic peptide onto tumours or other disease cells to induce their recognition by T cells. Peptide-exchange proteins and methods for their use are provided.