公开(公告)号：US20190309286A1

公开(公告)日：2019-10-10

申请号：US16282155

申请日：2019-02-21

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkeviciute

IPC: C12N15/10 ,  C12N15/62 ,  C40B40/10

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US11279925B2

公开(公告)日：2022-03-22

申请号：US16282155

申请日：2019-02-21

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkevi{hacek over (c)}iūte

IPC: C40B50/06 ,  C12N15/10 ,  C12N15/62 ,  C40B40/10 ,  C40B30/04

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US11525133B2

公开(公告)日：2022-12-13

申请号：US16428451

申请日：2019-05-31

Applicant: Cambridge Enterprise Limited

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkevi{hacek over (c)}iüte

IPC: C40B30/04 ,  C12N15/10 ,  C12N15/62 ,  C40B40/10 ,  C40B50/06

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US20220090054A1

公开(公告)日：2022-03-24

申请号：US17407074

申请日：2021-08-19

Applicant: Cambridge Enterprise Limited

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkeviciüte

IPC: C12N15/10 ,  C40B40/10 ,  C12N15/62 ,  C40B50/06 ,  C40B30/04

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.

公开(公告)号：US20190352637A1

公开(公告)日：2019-11-21

申请号：US16428451

申请日：2019-05-31

Applicant: Cambridge Enterprise Limited

Inventor： Laura Itzhaki ,  Alberto Perez Riba ,  Pamela Rowling ,  Grasilda Zenkeviciute

IPC: C12N15/10 ,  C12N15/62 ,  C40B40/10

Abstract: This invention relates to modular proteins that interact with one or more target molecules. The chimeric proteins comprise two or more repeat domains, such as tetratricopeptide repeat domains; inter-repeat loops linking the repeat domains; and one or more peptide ligands. Each peptide ligand is located in an inter-repeat loop or at the N or C terminus of the chimeric protein. The peptide ligands may include heterologous peptidyl binding motifs, such as short linear motifs (SLiMs). Chimeric proteins with various configurations and methods for their production and use are provided.