公开(公告)号：US6143304A

公开(公告)日：2000-11-07

申请号：US376755

申请日：1999-08-17

申请人： Camilo Canel ,  Franck E. Dayan ,  Rita M. Moraes ,  Charles L. Burandt

发明人： Camilo Canel ,  Franck E. Dayan ,  Rita M. Moraes ,  Charles L. Burandt

IPC分类号： A61K36/29 ,  A61K35/78

CPC分类号： A61K36/29

摘要： Enhanced recovery of podophyllotoxin from biological sources is achieved through disruption or permeabilization of the physical integrity of cells and tissues in the presence of sufficient moisture so as to allow endogenous enzymes to convert podophyllotoxin glucosides to podophyllotoxin. Extraction of the podophyllotoxin from the plant material is then achieved by use of an organic solvent. Podophyllotoxin is used as an intermediate in the production of the antitumor agent etoposide and its analogues.

摘要翻译： 通过在足够的水分存在下细胞和组织的物理完整性的破坏或透化来实现来自生物来源的鬼臼毒素的恢复，从而允许内源性酶将鬼臼毒素葡糖苷转化为鬼臼毒素。 然后通过使用有机溶剂来从植物材料中提取鬼臼毒素。 鬼臼毒素用作制备抗肿瘤剂依托泊甙及其类似物的中间体。