公开(公告)号：US20040204480A1

公开(公告)日：2004-10-14

申请号：US10790943

申请日：2004-03-02

Applicant: Cancer Research Technology Limited

Inventor： William R. Wilson ,  Bronwyn G. Siim

IPC: A61K031/353 ,  A61K031/7072 ,  A61K031/7048 ,  A61K031/704

CPC classification number: A61K31/66 ,  A61K31/352 ,  A61K31/4353 ,  A61K31/475 ,  A61K31/505 ,  A61K31/65 ,  A61K31/70 ,  A61K31/7034 ,  A61K33/24 ,  A61K2300/00

Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract translation: 本发明涉及化合物5,6-二甲基呫吨酮-4-乙酸（DMXAA）与选自铂化合物，长春花生物碱，烷化剂，蒽环类，拓扑异构酶I抑制剂，抗代谢物和拓扑异构酶II抑制剂的化合物的协同组合，其中 具有抗肿瘤活性。 优选地，本发明涉及化合物5,6-二甲基呫吨酮-4-乙酸（DMXAA）和选自卡铂，吉西他滨，顺铂，5-氟尿嘧啶，环磷酰胺，依托泊苷，长春新碱，多柔比星和伊立替康的化合物的协同组合。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有这些组合的药物组合物。 本发明进一步提供了制备本发明组合的方法。