公开(公告)号：US20240174634A1

公开(公告)日：2024-05-30

申请号：US18265063

申请日：2021-12-10

申请人： Cancer Research Technology Limited

发明人： Christopher Stephen KERSHAW ,  Mohammed ALJARAH ,  Dan NICULESCU-DUVAZ ,  Mark Philip DODSWORTH ,  Cinzia BORDONI ,  Caroline SPRINGER

IPC分类号： C07D401/12 ,  A61P35/00 ,  C07D215/227 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D401/12 ,  A61P35/00 ,  C07D215/227 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain aldehyde dehydrogenase inhibitor compounds (also referred to herein as “ALDHI compounds”), that, inter alia, inhibit aldehyde dehydrogenase enzyme ALDH1A3. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit ALDH1A3 enzyme; to treat disorder (e.g., diseases) that are ameliorated by the inhibition of ALDHIA3 enzyme; to treat a proliferative disorder, cancer, obesity, diabetes, a cardiovascular disorder, etc.