公开(公告)号：US20180282418A1

公开(公告)日：2018-10-04

申请号：US15544323

申请日：2016-01-21

Applicant: Cancer Research Technology Limited

Inventor： Roy Bicknell ,  Peter Noy ,  Kabir Ali Khan

IPC: C07K16/28 ,  G01N33/50

Abstract: The invention provides a method of inhibiting angiogenes—is in an individual, the method comprising administering to the individual an agent that inhibits the interaction between CLEC14A and MMNR2. The inhibitor may be an antibody, a polypeptide, a peptide, a polynucleotide, a peptidomimetic, a natural product, a carbohydrate, an aptamer or a small molecule

公开(公告)号：US10808031B2

公开(公告)日：2020-10-20

申请号：US15544323

申请日：2016-01-21

Applicant: Cancer Research Technology Limited

Inventor： Roy Bicknell ,  Peter Noy ,  Kabir Ali Khan

IPC: C07K16/28 ,  C07K16/30 ,  A01K67/027 ,  A61P35/00 ,  G01N33/50 ,  A61K39/00

Abstract: The invention provides a method of inhibiting angiogenesis in an individual, the method comprising administering to the individual an agent that inhibits the interaction between CLEC14A and MMRN2. The inhibitor may be an antibody, a polypeptide, a peptide, a polynucleotide, a peptidomimetic, a natural product, a carbohydrate, an aptamer or a small molecule.

公开(公告)号：US11919959B2

公开(公告)日：2024-03-05

申请号：US16992497

申请日：2020-08-13

Applicant: Cancer Research Technology Limited

Inventor： Roy Bicknell ,  Peter Noy ,  Kabir Ali Khan

IPC: C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  G01N33/50 ,  A61K39/00

CPC classification number: C07K16/2851 ,  A01K67/0278 ,  A61P35/00 ,  C07K16/30 ,  G01N33/5008 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/76

Abstract: The invention provides a method of inhibiting angiogenesis in an individual, the method comprising administering to the individual an agent that inhibits the interaction between CLEC14A and MMRN2. The inhibitor may be an antibody, a polypeptide, a peptide, a polynucleotide, a peptidomimetic, a natural product, a carbohydrate, an aptamer or a small molecule.

公开(公告)号：US20210070867A1

公开(公告)日：2021-03-11

申请号：US16992497

申请日：2020-08-13

Applicant: Cancer Research Technology Limited

Inventor： Roy Bicknell ,  Peter Noy ,  Kabir Ali Khan

IPC: C07K16/28 ,  C07K16/30 ,  A01K67/027 ,  A61P35/00 ,  G01N33/50

Abstract: The invention provides a method of inhibiting angiogenesis in an individual, the method comprising administering to the individual an agent that inhibits the interaction between CLEC14A and MMRN2. The inhibitor may be an antibody, a polypeptide, a peptide, a polynucleotide, a peptidomimetic, a natural product, a carbohydrate, an aptamer or a small molecule.