公开(公告)号：US09683032B2

公开(公告)日：2017-06-20

申请号：US14439411

申请日：2013-10-29

Applicant: Cancer Research Technology Limited

Inventor： Jorg Klingelhöfer ,  Noona Ambartsumian ,  Mariam Grigorian ,  Eugene Lukanidin

IPC: C07K16/18 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574 ,  A61K39/00 ,  A61N5/10

CPC classification number: C07K16/18 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N2005/1098 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57415 ,  G01N2333/4727

Abstract: Anti-S100A4 antibody molecules that are capable of inhibiting the biological activity of S100A4 in promoting tumor progression and/or in inducing tumor metastasis are described. The antibody molecules are also useful in the treatment of inflammatory conditions. The properties of the antibodies are demonstrated using in vitro and in vivo assays.

公开(公告)号：US20160159888A1

公开(公告)日：2016-06-09

申请号：US14439411

申请日：2013-10-29

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Jorg Klingelhöfer ,  Noona Ambartsumian ,  Mariam Grigorian ,  Eugene Lukanidin

IPC: C07K16/18 ,  A61K45/06 ,  G01N33/574 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N2005/1098 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57415 ,  G01N2333/4727

Abstract: Anti-S100A4 antibody molecules that are capable of inhibiting the biological activity of S100A4 in promoting tumour progression and/or in inducing tumour metastasis are described. The antibody molecules are also useful in the treatment of inflammatory conditions. The properties of the antibodies are demonstrated using in vitro and in vivo assays.

Abstract translation: 描述了能够抑制S100A4在促进肿瘤进展和/或诱导肿瘤转移中的生物学活性的抗S100A4抗体分子。 抗体分子也可用于治疗炎性病症。 使用体外和体内测定来证明抗体的性质。