公开(公告)号：US09604994B2

公开(公告)日：2017-03-28

申请号：US14285007

申请日：2014-05-22

Applicant: Cancer Research Technology Limited ,  Ignyta, Inc.

Inventor： Bruce D Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R Ott ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07F7/08 ,  A61P35/00

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.