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![BINDING MOLECULES TO ARGINASE II [ARG2]](/abs-image/US/2022/12/22/US20220403048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220403048A1
公开(公告)日：2022-12-22
申请号：US17637052
申请日：2020-08-21
发明人： Alexandra Addyman , Mark Austin , Michelle Barnard , Vincenzo Cerundolo , Denice Chan , Agata Diamandakis , Sebastian Fielder , Maria Groves , Stuart Haynes , Sarah Holt , Lesley Jenkinson , Stephanie Keswick , Fiona McLaughlin , Pooja Sharma , Yoko Shibata , Louise Slater , Jessica Whitehouse , Mark D Carr , Daniel Burschowsky , Chitra Seewooruthun
摘要： An isolated antigen-binding protein characterised in that it is capable of binding specifically to human Arginase II (ARG2) and inhibiting the enzyme activity of human ARG2.
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公开(公告)号：US09834598B2
公开(公告)日：2017-12-05
申请号：US14435520
申请日：2013-10-15
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
IPC分类号： A61K39/395 , C07K16/18 , A61P25/28 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/60 , C07K2317/622 , C07K2317/92
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US20220251181A1
公开(公告)日：2022-08-11
申请号：US17673449
申请日：2022-02-16
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgard
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US20210009665A1
公开(公告)日：2021-01-14
申请号：US16864439
申请日：2020-05-01
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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5.发明授权公开(公告)号：US12110336B2
公开(公告)日：2024-10-08
申请号：US17020247
申请日：2020-09-14
申请人： MedImmune Limited
发明人： Matthew Gardener , Jayne Hammersley , Maria Groves , Gareth Rees , Sadhana Podichetty , Andrew Billinton
IPC分类号： C07K16/28
CPC分类号： C07K16/2872 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides antibodies and antigen-binding fragments capable of binding PrPC. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.
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公开(公告)号：US20240294619A1
公开(公告)日：2024-09-05
申请号：US18604668
申请日：2024-03-14
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
IPC分类号： C07K16/18 , A61K38/17 , A61K39/00 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61P25/28 , A61K38/1716 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/60 , C07K2317/622 , C07K2317/92
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US10808034B2
公开(公告)日：2020-10-20
申请号：US16093687
申请日：2017-04-04
申请人： MedImmune Limited
发明人： Matthew Gardener , Jayne Hammersley , Maria Groves , Gareth Rees , Sadhana Podichetty , Andrew Billinton
摘要： The present disclosure provides antibodies and antigen-binding fragments capable of binding PrPC. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.
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公开(公告)号：US20180105585A1
公开(公告)日：2018-04-19
申请号：US15793510
申请日：2017-10-25
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
IPC分类号： C07K16/18 , A61K39/395 , A61K39/00
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US12098191B2
公开(公告)日：2024-09-24
申请号：US17673449
申请日：2022-02-16
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgard
IPC分类号： C07K16/18 , A61K38/17 , A61K39/00 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , A61P25/28 , A61K38/1716 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/60 , C07K2317/622 , C07K2317/92
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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公开(公告)号：US11286297B2
公开(公告)日：2022-03-29
申请号：US16864439
申请日：2020-05-01
申请人： MedImmune Limited
发明人： Maria Groves , Suzanne Gustavsson , Kina Höglund , Chris Lloyd , Adrian Nickson , Camilla Niva , Sylvia Simon , David Lowne , Fraser Welsh , Per-Ola Freskgärd
IPC分类号： C07K16/18 , A61P25/28 , A61K39/395 , A61K38/17 , A61K39/00
摘要： Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.
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