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39 条记录 (耗时 0.022 秒)

    Quinoline Derivatives as NK-3 and NK-2 Antagonists
    1.
    发明申请
    Quinoline Derivatives as NK-3 and NK-2 Antagonists 审中-公开
    喹啉衍生物作为NK-3和NK-2拮抗剂

    公开(公告)号：US20070015766A1

    公开(公告)日：2007-01-18

    申请号：US11426414

    申请日：2006-06-26

    申请人： Carlo Farina ,  Stefania Gagliardi ,  Giuseppe Giardina ,  Mario Grugni ,  Marisa Martinelli ,  Guy Marguerite Marie Gerard Nadler

    发明人： Carlo Farina ,  Stefania Gagliardi ,  Giuseppe Giardina ,  Mario Grugni ,  Marisa Martinelli ,  Guy Marguerite Marie Gerard Nadler

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D401/12 ,  C07D215/52

    摘要： Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: wherein: R1 is H or alkyl; R2 is aryl, cycloalkyl or heteroaryl; R3 is H or C1-3 alkyl, optionally substituted by one or more fluorines; R4 is H, R8NR9R10, R11R13 or R11R12R13; or R5 is branched or linear alkyl, cycloalkyl, aryl, arylalkyl, or a single or fused ring aromatic heterocyclic group; a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and the use of such compounds and composition in medicine.

    摘要翻译： 某些下式（I）化合物或其药学上可接受的盐或水合物：其中：R 1是H或烷基; R 2是芳基，环烷基或杂芳基; R 3是H或C 1-3烷基，任选被一个或多个氟取代; R 4是H，R 8 NR 9 R 10，R 11 R 13或13个R 12 R 13 13; 或R 5是支链或直链烷基，环烷基，芳基，芳烷基或单或稠环芳族杂环基; 制备这些化合物的方法，包含这些化合物的药物组合物和这些化合物的用途以及这些化合物和组合物在医药中的用途。

    Indole derivatives and their use for the treatment of osteoporosis amongst other applications
    10.
    发明授权
    Indole derivatives and their use for the treatment of osteoporosis amongst other applications 失效
    吲哚衍生物及其在其他应用中用于治疗骨质疏松症的用途

    公开(公告)号：US06787550B1

    公开(公告)日：2004-09-07

    申请号：US10018443

    申请日：2001-12-12

    申请人： Carlo Farina ,  Stefania Gagliardi ,  Pietro A. Novella

    发明人： Carlo Farina ,  Stefania Gagliardi ,  Pietro A. Novella

    IPC分类号： C07D40112

    CPC分类号： C07D209/18 ,  C07D401/12 ,  C07D403/12

    摘要： A compound of formula (1) or a salt thereof, or a solvate thereof, wherein; R1 and R2 each independently represents C1-6alkoxy or halo; R3 and R4 each independently represents hydrogen, C1-6alkoxy, arylC1-6alkoxy, hydroxy, carboxyC1-6alkoxy, hydroxyC1-6alkoxy, dihydroxyC1-6alkoxy, mono- and di-(C1-6alkyl)aminoC1-6alkoxy or aminoC1-6alkoxy, and; R5 represents —NRsRt wherein Rs and Rt each independently represent hydrogen, unsubstituted or substituted C1-6alkyl, or unsubstituted or substituted heterocyclyl, a process for the preparation of such a compound, a pharmaceutical composition containing such a compound and the use of the compound or composition in medicine.

    摘要翻译： 式（1）的化合物或其盐或其溶剂合物，其中：R 1和R 2各自独立地表示C 1-6烷氧基或卤素; R 3和R 4各自独立地表示氢，C 1-6烷氧基，芳基C 1-6烷氧基，羟基，羧基C 1 1-6烷氧基，羟基C 1-6烷氧基，二羟基C 1-6烷氧基，单 - 和二 - （C 1-6烷基）氨基C 1-6烷氧基或氨基C 1-6烷氧基，和R 5表示-NR s R t，其中R 5和R t各自独立地表示氢，未取代或取代的C 1-6烷基 ，或未取代或取代的杂环基，制备这种化合物的方法，含有这种化合物的药物组合物和药物中化合物或组合物的用途。