公开(公告)号：US20210290769A1

公开(公告)日：2021-09-23

申请号：US17264519

申请日：2019-08-01

Applicant: Carnegie Mellon University

Inventor： Alan J. Russell ,  Hironobu Murata ,  Sheiliza Carmali ,  Krzysztof Matyjaszewski

IPC: A61K47/58 ,  A61K38/47

Abstract: Materials and methods for targeted and controlled addition of polymers to proteins are provided herein. For example, the methods provided herein can include contacting a protein with (i) an inactive controlled radical polymerization (CRP) initiator blocker that can reacts with amino groups on the protein but cannot serve as an initiator for polymer addition, and (ii) an active CRP initiator that reacts with amino groups on the protein and also includes a group through which a polymer can be coupled to the initiator.