公开(公告)号：US20240207255A1

公开(公告)日：2024-06-27

申请号：US18419894

申请日：2024-01-23

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carranico ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  A61K31/573 ,  A61K31/69 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04

CPC分类号： A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69 ,  A61K2300/00

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US11185543B2

公开(公告)日：2021-11-30

申请号：US16859357

申请日：2020-04-27

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  James Carmichael ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  C07D401/04 ,  A61K31/573 ,  A61P35/02 ,  A61K38/05 ,  A61P35/00 ,  A61K31/69

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US10675281B2

公开(公告)日：2020-06-09

申请号：US16430189

申请日：2019-06-03

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  Matthew D. Correa ,  Joshua Hansen ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Nanfei Zou

IPC分类号： C07D401/04 ,  A61K31/496 ,  A61K31/573 ,  A61P35/02 ,  A61K38/05 ,  A61P35/00 ,  A61K31/69

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US11370777B2

公开(公告)日：2022-06-28

申请号：US16737739

申请日：2020-01-08

申请人： Celgene Corporation

发明人： Gerald D. Artman, III ,  Antonio C. Ferretti ,  Lianfeng Huang ,  Udaykumar Jain ,  Hon-Wah Man ,  Paula A. Tavares-Greco ,  Wenju Wu ,  Nancy Nienhua Tsou ,  Zhiwei Yin

IPC分类号： C07D401/14

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.

公开(公告)号：US12029738B2

公开(公告)日：2024-07-09

申请号：US17521432

申请日：2021-11-08

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69

CPC分类号： A61K31/496 ,  A61K31/573 ,  A61K38/05 ,  A61P35/00 ,  A61P35/02 ,  C07D401/04 ,  A61K31/69 ,  A61K2300/00 ,  A61K31/496 ,  A61K2300/00 ,  A61K31/573 ,  A61K2300/00 ,  A61K38/05 ,  A61K2300/00

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20190282567A1

公开(公告)日：2019-09-19

申请号：US16430189

申请日：2019-06-03

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  C07D401/04 ,  A61K31/573 ,  A61P35/02 ,  A61K38/05 ,  A61P35/00

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US10357489B2

公开(公告)日：2019-07-23

申请号：US16030695

申请日：2018-07-09

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  James Carmichael ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： C07D241/04 ,  C07D295/00 ,  A61K31/496 ,  A61P35/02 ,  A61K31/573 ,  A61K38/05 ,  C07D401/04 ,  A61P35/00 ,  A61K31/69

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20220289713A1

公开(公告)日：2022-09-15

申请号：US17827491

申请日：2022-05-27

申请人： Celgene Corporation

发明人： Gerald D. Artman, III ,  Antonio C. Ferretti ,  Lianfeng Huang ,  Udaykumar Jain ,  Hon-Wah Man ,  Paula A. Tavares-Greco ,  Wenju Wu ,  Nancy Nienhua Tsou ,  Zhiwei Yin

IPC分类号： C07D401/14

摘要： Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.

公开(公告)号：US20220280505A1

公开(公告)日：2022-09-08

申请号：US17521432

申请日：2021-11-08

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  A61P35/02 ,  A61K31/573 ,  A61K38/05 ,  C07D401/04 ,  A61P35/00

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

公开(公告)号：US20200253964A1

公开(公告)日：2020-08-13

申请号：US16859357

申请日：2020-04-27

申请人： Celgene Corporation

发明人： Matthew D. Alexander ,  Gerald D. Artman, III ,  Gordon L. Bray ,  James Carmichael ,  Soraya Carrancio ,  Brian E. Cathers ,  Matthew D. Correa ,  Joshua Hansen ,  Courtney G. Havens ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Xiaoling Lu ,  Hon-Wah Man ,  Mark A. Nagy ,  Rama K. Narla ,  Joseph R. Piccotti ,  Daniel W. Pierce ,  Paula A. Tavares-Greco ,  Brandon W. Whitefield ,  Lilly L. Wong ,  Nanfei Zou

IPC分类号： A61K31/496 ,  A61P35/00 ,  C07D401/04 ,  A61K38/05 ,  A61K31/573 ,  A61P35/02

摘要： Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.