公开(公告)号：US20160193208A1

公开(公告)日：2016-07-07

申请号：US14847545

申请日：2015-09-08

申请人： Cell Signaling Technology, Inc.

发明人： Klarisa Rikova ,  Roberto Polakiewicz ,  Ailan Guo ,  Katherine Eleanor Crosby ,  Quingfu Zeng ,  Kimberly A Lee

IPC分类号： A61K31/506 ,  G01N33/574

CPC分类号： A61K31/506 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2333/71

摘要： The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFRα-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFRα is expressed, and for determining whether a compound inhibits the progression of a PDGFRα-expressing mammalian NSCLC tumor.

摘要翻译： 本发明公开了一种以前未确认的哺乳动物非小细胞肺癌（NSCLC）的亚群，其中血小板衍生生长因子受体α（PDGFRα）被表达并正在驱动该疾病，并且提供了鉴定哺乳动物NSCLC肿瘤属于 其中表达PDGFRα的NSCLC肿瘤的子集，以及用于鉴定可能对PDGFRα抑制性治疗反应的NSCLC肿瘤。 本发明还提供抑制其中表达PDGFRα的哺乳动物NSCLC肿瘤进展的方法，以及用于确定化合物是否抑制表达PDGFRα的哺乳动物NSCLC肿瘤进展的方法。