公开(公告)号：US20180213755A1

公开(公告)日：2018-08-02

申请号：US15575988

申请日：2016-04-20

申请人： Central Institute for Experimental Animals

发明人： Mamoru ITO ,  Ikumi KATANO

IPC分类号： A01K67/027 ,  C12N15/85

CPC分类号： A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C07K14/5443 ,  C12N15/8509 ,  C12N2015/8518

摘要： An object of the present invention is to provide a mouse that enables the functions of human NK cell to be studied. A DNA consisting of a nucleotide sequence represented by SEQ ID NO: 1, which is a gene region comprising a DNA in which a cDNA sequence encoding interleukin 15 (IL-15) is operably ligated to a cDNA sequence encoding the signal peptide of human interleukin (IL-2), is inserted to immunodeficient mouse cDNA. In NOD-scid, IL-2rγnull-hIL-15 Tg mice thus generated, hCD56+ cell having a concentration sufficient for conducting in vivo study on human mature NK cell are detected for at least 6 months after transplantation.