公开(公告)号：US20240043935A1

公开(公告)日：2024-02-08

申请号：US18227831

申请日：2023-07-28

申请人： Centre for Novostics Limited

发明人： Yuk-Ming Dennis Lo ,  Peiyong Jiang ,  Kwan Chee Chan ,  Masashi Yukawa ,  Lu Ji ,  Jinyue Bai

IPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6869 ,  G16B20/10 ,  G16B40/00

CPC分类号： C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6869 ,  G16B20/10 ,  G16B40/00 ,  C12Q2600/154 ,  C12Q2600/158

摘要： Measuring quantities (e.g., relative frequencies) of particular sequence motifs of cell-free DNA fragments in a biological sample can be used to analyze the biological sample. The particular sequence motifs or sequence sizes in certain genomic regions may indicate a histone modification. The sequence motifs and/or sizes can be used to measure a property of the sample (e.g., fractional concentration of a tissue type or a characteristic of the tissue type), to measure an amount of histone modifications, to determine a condition of the organism based on such measurements, and to enrich a biological sample for clinically-relevant DNA. Different tissue types can exhibit different patterns for the relative frequencies of the sequence motifs. Measures of the relative frequencies of sequence motifs of cell-free DNA can be used for analysis.