公开(公告)号：US20140088042A1

公开(公告)日：2014-03-27

申请号：US13949346

申请日：2013-07-24

Applicant: Cephalon, Inc.

Inventor： Raffaella Bernardini ,  Alberto Bernareggi ,  Paolo G. Cassara ,  Sankar Chatterjee ,  Germano D'Arasmo ,  Sergio De Munari ,  Edmondo Ferretti ,  Mohamed Iqbal ,  Ernesto Menta ,  Patricia A. Messina McLaughlin ,  Ambrogio Oliva

IPC: A61K31/69 ,  A61K45/06 ,  C07F5/02

CPC classification number: A61K31/69 ,  A61K45/06 ,  C07F5/025

Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Abstract translation: 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。

公开(公告)号：US09233115B2

公开(公告)日：2016-01-12

申请号：US13949346

申请日：2013-07-24

Applicant: Cephalon, Inc.

Inventor： Raffaella Bernardini ,  Alberto Bernareggi ,  Paolo G. Cassara ,  Sankar Chatterjee ,  Germano D'Arasmo ,  Sergio De Munari ,  Edmondo Ferretti ,  Mohamed Iqbal ,  Ernesto Menta ,  Patricia A. Messina McLaughlin ,  Ambrogio Oliva

IPC: A61K31/69 ,  A61K45/06 ,  C07F5/02

CPC classification number: A61K31/69 ,  A61K45/06 ,  C07F5/025

Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.