公开(公告)号：US20180179159A1

公开(公告)日：2018-06-28

申请号：US15903150

申请日：2018-02-23

Applicant: Cephalon, Inc.

Inventor： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D211/44 ,  C07D495/04 ,  C07D401/14 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D495/02 ,  C07D491/048 ,  C07D471/08 ,  C07D471/04 ,  C07D471/02 ,  C07D417/14 ,  C07D417/12 ,  C07D409/14 ,  C07D405/12 ,  C07D405/06 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14 ,  C07D409/12

CPC classification number: C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses

公开(公告)号：US09902696B2

公开(公告)日：2018-02-27

申请号：US15185710

申请日：2016-06-17

Applicant: Cephalon, Inc.

Inventor： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D211/44 ,  C07D495/04 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D409/12 ,  C07D409/14 ,  C07D495/02 ,  C07D471/08 ,  C07D471/04 ,  C07D401/14 ,  C07D417/14 ,  C07D417/12 ,  C07D491/048 ,  C07D405/12 ,  C07D405/06 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14 ,  C07D471/02

CPC classification number: C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US20160368874A1

公开(公告)日：2016-12-22

申请号：US15185710

申请日：2016-06-17

Applicant: Cephalon, Inc.

Inventor： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D211/44 ,  C07D405/12 ,  C07D471/04 ,  C07D405/14 ,  C07D491/048 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D401/14 ,  C07D409/12 ,  C07D495/04 ,  C07D417/12 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04

CPC classification number: C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

Abstract: Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

Abstract translation: 本文描述了具有作为脂肪酸合成酶抑制剂的活性的根据式（I）的1,4-取代的哌啶化合物。 本文还描述了含有所述1,4-取代的哌啶化合物的药物组合物，以及通过施用本文所述的一种或多种化合物或药物制剂来治疗由脂肪酸合酶介导的疾病的方法。 本文还描述了合成所述化合物的方法，包括所述1,4-取代的哌啶化合物和用于那些合成的合成中间体。