公开(公告)号：US20030216419A1

公开(公告)日：2003-11-20

申请号：US10422164

申请日：2003-04-24

Applicant: Cephalon, Inc.

Inventor： Robert L. Hudkins

IPC: A61K031/4745 ,  A61K031/407 ,  C07D487/14

CPC classification number: C07D471/14 ,  C07D487/04 ,  C07D491/14 ,  C07D495/14

Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

公开(公告)号：US20040186157A1

公开(公告)日：2004-09-23

申请号：US10755505

申请日：2004-01-12

Applicant: Cephalon, Inc.

Inventor： Robert L. Hudkins ,  Dandu R. Reddy ,  Jasbir Singh ,  Rabindranath Tripathy ,  Ted Underiner

IPC: A61K031/407 ,  C07D209/56

CPC classification number: C07D487/04 ,  C07D209/94

Abstract: The present invention is directed to cyclic substituted fused pyrrolocarbazoles and isoindolones. The invention also is directed to methods for making and using the cyclic substituted fused pyrrolocarbazoles and isoindolones.

Abstract translation: 本发明涉及环状取代的稠合吡咯并咔唑和异吲哚酮。 本发明还涉及制备和使用环状取代的稠合吡咯并咔唑和异吲哚酮的方法。

公开(公告)号：US20020147341A1

公开(公告)日：2002-10-10

申请号：US10062159

申请日：2002-02-01

Applicant: Cephalon, Inc.

Inventor： Robert L. Hudkins

IPC: C07D498/14 ,  C07D471/14 ,  A61K031/407

CPC classification number: C07D471/14 ,  C07D487/04 ,  C07D491/14 ,  C07D495/14

Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

公开(公告)号：US20030203957A1

公开(公告)日：2003-10-30

申请号：US10400136

申请日：2003-03-26

Applicant: Cephalon, Inc.

Inventor： Diane E. Gingrich ,  Robert L. Hudkins

IPC: A61K031/407 ,  C07D471/02

CPC classification number: C07D487/04 ,  A61K31/407

Abstract: The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.

公开(公告)号：US20030087899A1

公开(公告)日：2003-05-08

申请号：US10146680

申请日：2002-05-15

Applicant: Cephalon, Inc

Inventor： Lisa D. Aimone ,  Robert L. Hudkins ,  Matthew S. Miller

IPC: A61K031/553 ,  A61K031/542 ,  A61K031/5383 ,  A61K031/4985

CPC classification number: A61K31/553

Abstract: Novel methods for the treatment and/or prevention of pain are presented. The methods may comprise administering to a subject in need thereof an effective amount of a stress-activated protein kinase inhibitor. Preferred compounds for use in the methods include fused pyrrolocarbazole compounds.

Abstract translation: 提出了治疗和/或预防疼痛的新方法。 所述方法可包括向有需要的受试者施用有效量的应激活化蛋白激酶抑制剂。 用于该方法的优选化合物包括稠合的吡咯并咔唑化合物。