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公开(公告)号：US11912719B2
公开(公告)日：2024-02-27
申请号：US17565231
申请日：2021-12-29
IPC分类号： A61K31/4725 , C07D217/22 , C07D498/08 , C07D401/12 , C07D405/14 , C07D471/04 , C07D403/12
CPC分类号： C07D498/08 , C07D401/12 , C07D403/12 , C07D405/14 , C07D471/04
摘要： The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
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公开(公告)号：US20220119406A1
公开(公告)日：2022-04-21
申请号：US17565231
申请日：2021-12-29
IPC分类号： C07D498/08 , C07D401/12 , C07D405/14 , C07D471/04 , C07D403/12
摘要： The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
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公开(公告)号：US11248004B2
公开(公告)日：2022-02-15
申请号：US16867162
申请日：2020-05-05
IPC分类号： A61K31/4725 , C07D217/22 , C07D498/08 , C07D401/12 , C07D405/14 , C07D471/04 , C07D403/12
摘要： The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
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公开(公告)号：US20200262844A1
公开(公告)日：2020-08-20
申请号：US16867162
申请日：2020-05-05
IPC分类号： C07D498/08 , C07D401/12 , C07D403/12 , C07D471/04 , C07D405/14
摘要： The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
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