-
公开(公告)号：US08138195B2
公开(公告)日：2012-03-20
申请号：US11110204
申请日：2005-04-20
申请人： Chanchal Sadhu , Kenneth O. Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Kenneth O. Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K31/52 , A01N43/90 , C07D487/04
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kδ）活性的方法，以及治疗PI3Kδ在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3Kδ的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kδ活性的化合物，包括选择性抑制PI3Kδ活性的化合物。 还提供了使用PI3Kδ抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了在体外和体内使用PI3Kδ抑制化合物抑制PI3Kδ介导的过程的方法。
-
公开(公告)号：US06949535B2
公开(公告)日：2005-09-27
申请号：US10697912
申请日：2003-10-30
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K31/517 , A61K31/52 , A61P3/10 , A61P7/08 , A61P9/00 , A61P9/10 , A61P11/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/02 , A61P27/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , A61K31/33 , C07D239/72
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kdelta）活性的方法，以及治疗PI3Kdelta在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3Kdelta的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kdelta活性的化合物，包括选择性抑制PI3Kdelta活性的化合物。 还提供了使用PI3Kdelta抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了使用PI3Kdelta抑制化合物在体外和体内抑制PI3Kdelta介导的过程的方法。
-
公开(公告)号：US08653077B2
公开(公告)日：2014-02-18
申请号：US13247962
申请日：2011-09-28
申请人： Chanchal Sadhu , Kennith O. Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Kennith O. Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： C07D413/12 , C07D413/14 , A01N43/54 , C07D403/12 , A61K31/517 , A61P3/14
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kdelta）活性的方法，以及治疗PI3Kdelta在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3Kdelta的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kdelta活性的化合物，包括选择性抑制PI3Kdelta活性的化合物。 还提供了使用PI3Kdelta抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了使用PI3Kdelta抑制化合物在体外和体内抑制PI3Kdelta介导的过程的方法。
-
公开(公告)号：US08637533B2
公开(公告)日：2014-01-28
申请号：US13399828
申请日：2012-02-17
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
-
公开(公告)号：US08623881B2
公开(公告)日：2014-01-07
申请号：US12575277
申请日：2009-10-07
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A01N43/90 , A61K31/52 , C07D487/00
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
-
公开(公告)号：US20120135994A1
公开(公告)日：2012-05-31
申请号：US13247962
申请日：2011-09-28
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K31/53 , C07D403/12 , C07D403/06 , A61K31/517 , A61K31/519 , A61P29/00 , A61P9/10 , A61P19/08 , A61P35/00 , A61P35/02 , A61P37/08 , A61P19/02 , A61P27/02 , A61P11/00 , A61P1/16 , A61P11/06 , C07D487/04
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
-
公开(公告)号：US20100168139A1
公开(公告)日：2010-07-01
申请号：US12575277
申请日：2009-10-07
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K31/52 , C07D473/00 , A61P19/02
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
-
公开(公告)号：US20100152211A1
公开(公告)日：2010-06-17
申请号：US12575367
申请日：2009-10-07
申请人： Chanchal SADHU , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal SADHU , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： A61K31/52 , C07D473/24 , C07D473/38 , C07D473/34 , A61P19/02 , A61P11/06 , A61P11/00 , A61P3/10 , A61P35/02
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kδ）活性的方法，以及治疗PI3Kδ在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3Kδ的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kδ活性的化合物，包括选择性抑制PI3Kδ活性的化合物。 还提供了使用PI3Kδ抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了在体外和体内使用PI3Kδ抑制化合物抑制PI3Kδ介导的过程的方法。
-
公开(公告)号：US08492389B2
公开(公告)日：2013-07-23
申请号：US12575367
申请日：2009-10-07
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： C07D487/00 , A01N43/90 , A61K31/52
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
-
公开(公告)号：US20120172591A1
公开(公告)日：2012-07-05
申请号：US13399828
申请日：2012-02-17
申请人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
发明人： Chanchal Sadhu , Ken Dick , Jennifer Treiberg , C. Gregory Sowell , Edward A. Kesicki , Amy Oliver
IPC分类号： C07D473/34 , C07D473/24 , C07D473/20 , C07D403/12 , C07D487/04 , C07D473/38 , C07D473/16
CPC分类号： A61K31/506 , C07D403/12 , C07D473/00 , C07D473/16 , C07D473/24 , C07D473/30 , C07D473/32 , C07D473/34 , C07D473/38 , C07D473/40 , C07D487/04 , C12N9/1205 , C12N9/99 , C12Y207/01137
摘要： Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
摘要翻译： 公开了抑制磷脂酰肌醇3-激酶δ同种型（PI3Kδ）活性的方法，以及治疗PI3Kδ在白细胞功能中起作用的疾病如免疫和炎症疾病的方法。 优选地，所述方法使用选择性抑制PI3Kδ的活性剂，而不显着抑制其它PI3K同种型的活性。 提供抑制PI3Kδ活性的化合物，包括选择性抑制PI3Kδ活性的化合物。 还提供了使用PI3Kδ抑制化合物抑制癌细胞生长或增殖的方法。 因此，本发明提供了在体外和体内使用PI3Kδ抑制化合物抑制PI3Kδ介导的过程的方法。
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.065 秒)
