专利检索 ap:("Chandra Vargeese" OR "Meena" OR "Nenad Svrzikapa" OR "Susovan Mohapatra" OR "Christopher J. Francis" OR "Gregory L. Verdine" OR "Anna Sokolovska") AND inv:"Susovan Mohapatra" 第 1 页

1.

发明申请
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 审中-公开

公开(公告)号：US20180216108A1

公开(公告)日：2018-08-02

申请号：US15746220

申请日：2016-07-22

申请人： Chandra Vargeese , Meena , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska

发明人： Chandra Vargeese , Meena , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska

IPC分类号： C12N15/113 , A61P25/28

摘要： Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.