公开(公告)号：US09556436B2

公开(公告)日：2017-01-31

申请号：US14747041

申请日：2015-06-23

申请人： Chang Gung University

发明人： Shin-Ru Shih ,  Chi-Jene Chen ,  Sheng-Yu Huang

IPC分类号： C12N15/11 ,  C12N15/113 ,  C12Q1/70

CPC分类号： C12N15/1131 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method of treating Influenza A is disclosed. The method includes the step of administering a pharmaceutical composition including an oligonucleotide complementary to a corresponding segment of the nucleotide sequence of microRNA-1290 (miR-1290) (SEQ ID NO: 1) to a subject suffering from Influenza A, wherein at least one of the nucleotides in the oligonucleotide is Thymidine phosphate.

摘要翻译： 公开了治疗流感A的方法。 该方法包括给予患有甲型流感的受试者的包含与微小RNA-1290（miR-1290）（SEQ ID NO：1）的核苷酸序列的相应片段互补的寡核苷酸的药物组合物给药的步骤，其中至少一种 寡核苷酸中的核苷酸是磷酸胸苷。

公开(公告)号：US11679102B2

公开(公告)日：2023-06-20

申请号：US17333117

申请日：2021-05-28

申请人： Chang Gung University

发明人： Shin-Ru Shih ,  Yu-An Kung ,  Huan-Jung Chiang ,  Chuan-Tien Hung ,  Yu-Nong Gong ,  Hsin-Ping Chiu ,  Chiung-Guei Huang ,  Peng-Nien Huang ,  Sheng-Yu Huang

IPC分类号： A61P31/16 ,  A61K31/4436 ,  A61K31/131 ,  A61K31/245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/499 ,  A61K9/00

CPC分类号： A61K31/4436 ,  A61K9/0053 ,  A61K31/131 ,  A61K31/245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/499 ,  A61P31/16

摘要： Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210386702A1

公开(公告)日：2021-12-16

申请号：US17333117

申请日：2021-05-28

申请人： Chang Gung University

发明人： Shin-Ru Shih ,  Yu-An Kung ,  Huan-Jung Chiang ,  Chuan-Tien Hung ,  Yu-Nong Gong ,  Hsin-Ping Chiu ,  Chiung-Guei Huang ,  Peng-Nien Huang ,  Sheng-Yu Huang

IPC分类号： A61K31/245 ,  A61K31/427 ,  A61K31/131 ,  A61K31/499

摘要： Disclosed herein is a method for inhibiting virus infection, including administering to a subject in need thereof an effective amount of a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof. Also disclosed is a method for inhibiting viral replication, including contacting a virus with a ferroptosis inhibitor or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160376597A1

公开(公告)日：2016-12-29

申请号：US14747041

申请日：2015-06-23

申请人： CHANG GUNG UNIVERSITY

发明人： Shin-Ru Shih ,  Chi-Jene Chen ,  Sheng-Yu Huang

IPC分类号： C12N15/113 ,  C12Q1/70

CPC分类号： C12N15/1131 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A method of treating Influenza A is disclosed. The method includes the step of administering a pharmaceutical composition including an oligonucleotide complementary to a corresponding segment of the nucleotide sequence of microRNA-1290 (miR-1290) (SEQ ID NO: 1) to a subject suffering from Influenza A, wherein at least one of the nucleotides in the oligonucleotide is Thymidine phosphate.

摘要翻译： 公开了治疗流感A的方法。 该方法包括给予患有甲型流感的受试者的包含与微小RNA-1290（miR-1290）（SEQ ID NO：1）的核苷酸序列的相应片段互补的寡核苷酸的药物组合物给药的步骤，其中至少一种 寡核苷酸中的核苷酸是磷酸胸苷。