Cyanoguanidines as cell proliferation inhibitors
    2.
    发明授权
    Cyanoguanidines as cell proliferation inhibitors 失效
    氰基胍类作为细胞增殖抑制剂

    公开(公告)号:US06197797B1

    公开(公告)日:2001-03-06

    申请号:US09424630

    申请日:1999-11-26

    IPC分类号: A61K3144

    CPC分类号: C07D213/75

    摘要: The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine being in the 3- or 4-position, in which formula R1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl nitro, amino, cyano, carboxy, or alkyl, alkoxy, or alkoxycarbonyl, the C-content of which can be from 1 to 4; X stands for a straight or branched C9-C20 carbon chain, saturated or unsaturated or Q—Ar—R; in which formula Ar stands for phenyl, Q stands for a C5-C20 divalent hydrocarbon radical which can be straight, branched, saturated or unsaturated and R stands for hydrogen or for one or more substituents which can be the same or different and are selected from the group consisting of: hydroxy, amino, halogen, trifluoromethyl, cyano, nitro, carboxy, carbamoyl, or alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 4; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.

    摘要翻译: 本发明涉及迄今为止未知的式(I)化合物或其互变异构形式,其中吡啶与3-或4-位的连接,式R1代表一个或多个可相同或不同的取代基 并且选自:氢,卤素,硝基三氟甲基,氨基,氰基,羧基或烷基,烷氧基或烷氧基羰基,其C含量可以为1至4; X代表饱和或不饱和的直链或支链C 9 -C 20碳链或Q-Ar-R; 其中式Ar代表苯基,Q代表可以是直链,支链,饱和或不饱和的C 5 -C 20二价烃基,R代表氢或一个或多个相同或不同的取代基,选自 由羟基,氨基,卤素,三氟甲基,氰基,硝基,羧基,氨基甲酰基或烷基,烷氧基,烷硫基,烷基氨基或烷氧基羰基组成的基团,其C含量可以为1至4; 和其药学上可接受的无毒盐和N-氧化物。 本化合物在人类和兽医实践中是有价值的。