公开(公告)号：US20120294863A1

公开(公告)日：2012-11-22

申请号：US13566827

申请日：2012-08-03

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/02

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫调节而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防CD70表达的癌症和免疫学障碍的方法，其包括向受试者施用CD70结合剂。

公开(公告)号：US20090074772A1

公开(公告)日：2009-03-19

申请号：US12265451

申请日：2008-11-05

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395 ,  A61P31/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。

公开(公告)号：US07491390B2

公开(公告)日：2009-02-17

申请号：US11251173

申请日：2005-10-14

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。

公开(公告)号：US08337838B2

公开(公告)日：2012-12-25

申请号：US12370151

申请日：2009-02-12

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫调节而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防CD70表达的癌症和免疫学障碍的方法，其包括向受试者施用CD70结合剂。

公开(公告)号：US20080138341A1

公开(公告)日：2008-06-12

申请号：US12016814

申请日：2008-01-18

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395 ,  A61P19/02 ,  A61P21/00 ,  A61P31/06 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。

公开(公告)号：US09051372B2

公开(公告)日：2015-06-09

申请号：US12265451

申请日：2008-11-05

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。

公开(公告)号：US08647624B2

公开(公告)日：2014-02-11

申请号：US12016814

申请日：2008-01-18

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。

公开(公告)号：US07641903B2

公开(公告)日：2010-01-05

申请号：US11735365

申请日：2007-04-13

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫调节而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防CD70表达的癌症和免疫学障碍的方法，其包括向受试者施用CD70结合剂。

公开(公告)号：US20090232806A1

公开(公告)日：2009-09-17

申请号：US12370151

申请日：2009-02-12

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫调节而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防CD70表达的癌症和免疫学障碍的方法，其包括向受试者施用CD70结合剂。

公开(公告)号：US20080138343A1

公开(公告)日：2008-06-12

申请号：US12016848

申请日：2008-01-18

申请人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

发明人： Che-Leung Law ,  Julie McEarchern ,  Alan F. Wahl

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734

摘要： Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.

摘要翻译： 公开了CD70结合剂，例如抗CD70抗体和衍生物，其诱导细胞毒性，细胞抑制或免疫抑制而不与治疗剂缀合，以及包含抗体或衍生物的药物组合物和试剂盒。 还公开了用于治疗和预防表达CD70的癌症和免疫学疾病的方法，包括向受试者施用CD70-结合剂。