公开(公告)号：US11787769B2

公开(公告)日：2023-10-17

申请号：US17735235

申请日：2022-05-03

申请人： Chicago Biosolutions, Inc. ,  The Board of Trustees of the University of Illinois

发明人： Lijun Rong ,  Irina Gaisina ,  Gregory R. Thatcher ,  Norton Peet

IPC分类号： C07D215/58 ,  A61P31/16 ,  A61K31/47 ,  A61K45/06

CPC分类号： C07D215/58 ,  A61K31/47 ,  A61K45/06 ,  A61P31/16

摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.

公开(公告)号：US20220267275A1

公开(公告)日：2022-08-25

申请号：US17735235

申请日：2022-05-03

申请人： Chicago Biosolutions, Inc. ,  The Board of Trustees of the University of Illinois

发明人： Lijun Rong ,  Irina Gaisina ,  Gregory R. Thatcher ,  Norton Peet

IPC分类号： C07D215/58 ,  A61K31/47 ,  A61K45/06 ,  A61P31/16

摘要： Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.