公开(公告)号：US20060189516A1

公开(公告)日：2006-08-24

申请号：US11208596

申请日：2005-08-23

申请人： Chiung-Lin Yang ,  Jui-Hsiang Chen ,  Shiao-Wen Tsai ,  Hsin-Nung Shih ,  Lih-Yuann Shih

发明人： Chiung-Lin Yang ,  Jui-Hsiang Chen ,  Shiao-Wen Tsai ,  Hsin-Nung Shih ,  Lih-Yuann Shih

IPC分类号： A61K38/16 ,  C07K14/47

CPC分类号： A61L27/58 ,  A61L27/20 ,  C08L5/08

摘要： This invention is concerned with a new method for producing cross-linked hyaluronic acid—protein bio-composites in various shapes. In the present process, a polysaccharide solution and a protein solution are mixed under moderate pH values in presence of salts to form a homogenous solution, which can be processed into various shapes, such as membrane, sponge, fiber, tube or micro-granular and so on. After then, the homogenous solution is subjected to a cross-linking reaction in organic solvent containing weak acid to produce an implantable bio composite material having excellent bio-compatibility, biodegradability, prolonged enzymatic degradation time, and good physical properties.

摘要翻译： 本发明涉及用于生产各种形状的交联透明质酸 - 蛋白质生物复合材料的新方法。 在本方法中，多糖溶液和蛋白质溶液在盐的存在下在中等pH值下混合以形成均匀的溶液，其可以加工成各种形状，例如膜，海绵，纤维，管或微粒，以及 所以。 然后，均匀溶液在含有弱酸的有机溶剂中进行交联反应，生成具有优异的生物相容性，生物降解性，延长的酶降解时间和良好物理性质的可植入生物复合材料。