NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING A DISINTEGRATION MATRIX
    2.
    发明申请
    NOVEL PHARMACEUTICAL COMPOSITIONS COMPRISING A DISINTEGRATION MATRIX 审中-公开
    包含消毒矩阵的新型药物组合物

    公开(公告)号:US20090142398A1

    公开(公告)日:2009-06-04

    申请号:US12273937

    申请日:2008-11-19

    IPC分类号: A61K9/10 A61K31/4184

    CPC分类号: A61K9/2077 A61K31/4184

    摘要: The present invention relates to a stable pharmaceutical composition comprising a pharmaceutically active substance having poor water solubility dispersed in a pharmaceutically acceptable disintegration matrix, said disintegration matrix comprising at least one pharmaceutically acceptable disintegrant, a pharmaceutically acceptable basic agent provided in a molar ratio of basic agent to active substance of 1:1 to 10:1, a water-insoluble pharmaceutically acceptable diluent, optionally, if desired or necessary at least one pharmaceutically acceptable excipients and/or pharmaceutically acceptable adjuvants, and optionally a pharmaceutically acceptable surfactant or emulsifier. The present invention also provides a process to make such.

    摘要翻译: 本发明涉及一种稳定的药物组合物,其包含分散在药学上可接受的崩解基质中的具有差的水溶性的药物活性物质,所述崩解基质包含至少一种药学上可接受的崩解剂,以碱性试剂的摩尔比提供的药学上可接受的碱性试剂 至1:1至10:1的活性物质,任选地,如果需要或必需的至少一种药学上可接受的赋形剂和/或药学上可接受的佐剂,以及任选的药学上可接受的表面活性剂或乳化剂的水不溶性药学上可接受的稀释剂。 本发明还提供了制造这样的方法。