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公开(公告)号：US07205414B2
公开(公告)日：2007-04-17
申请号：US11033573
申请日：2005-01-12
IPC分类号： C07D333/08 , C07D333/28
CPC分类号： C07D333/06
摘要： A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.
摘要翻译： 从3-卤代噻吩形成3-烷基噻吩或3-芳基噻吩的方法。 更具体地，通过在催化剂和2-甲基四氢呋喃溶剂的存在下使3-卤代噻吩与烷基镁卤化物或芳基镁卤化物格氏试剂反应制备3-烷基噻吩或3-芳基噻吩的Kumada偶联反应的改进。 2-甲基四氢呋喃溶剂允许较高浓度的格利雅试剂与最少或没有二噻吩基产物的产生相比，获得更高的产物产率并以比其它已知方法更低的成本。
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公开(公告)号：US20060155134A1
公开(公告)日：2006-07-13
申请号：US11033573
申请日：2005-01-12
IPC分类号： C07D333/08 , C07F3/02
CPC分类号： C07D333/06
摘要： A method for the formation of 3-alkylthiophenes or 3-arylthiophenes from 3-halothiophenes. More particularly, improvements on the Kumada coupling reaction for the production of 3-alkylthiophenes or 3-arylthiophenes by reacting a 3-halothiophene with an alkylmagnesiumhalide or arylmagnesiumhalide Grignard reagent in the presence of a catalyst and a 2-methyl tetrahydrofuran solvent. The 2-methyl tetrahydrofuran solvent allows for higher concentrations of the Grignard reagent with minimal or no dithienyl side product generation, achieving higher product yields and at a lower cost than other known methods.
摘要翻译： 从3-卤代噻吩形成3-烷基噻吩或3-芳基噻吩的方法。 更具体地，通过在催化剂和2-甲基四氢呋喃溶剂的存在下使3-卤代噻吩与烷基镁卤化物或芳基镁卤化物格氏试剂反应制备3-烷基噻吩或3-芳基噻吩的Kumada偶联反应的改进。 2-甲基四氢呋喃溶剂允许较高浓度的格利雅试剂与最少或没有二噻吩基产物的产生相比，获得更高的产物产率并以比其它已知方法更低的成本。
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