公开(公告)号：US20090074677A1

公开(公告)日：2009-03-19

申请号：US12008259

申请日：2008-01-08

申请人： Christine E. Marx ,  Jed E. Rose

发明人： Christine E. Marx ,  Jed E. Rose

IPC分类号： A61K9/12 ,  A61K31/57 ,  C12Q1/02 ,  G01N33/50

CPC分类号： A61K31/57 ,  G01N33/6896 ,  G01N33/94 ,  G01N2800/304 ,  Y10T436/200833

摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

摘要翻译： 提供了改善受试者神经精神障碍症状的方法。 还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉 障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法 在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法 用于改善受试者的创伤性脑损伤的症状，改善sl的方法 受试者的睡眠障碍以及用于改善受试者的认知功能的方法。 在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢​​表雄酮（DHEA），其药学上可接受的盐，其衍生物或其组合。

公开(公告)号：US20110288059A1

公开(公告)日：2011-11-24

申请号：US13191140

申请日：2011-07-26

申请人： Christine E. Marx ,  Jed E. Rose

发明人： Christine E. Marx ,  Jed E. Rose

IPC分类号： A61K31/57 ,  A61P25/00 ,  A61P25/08 ,  A61P25/22 ,  A61P25/18 ,  A61K31/56 ,  A61P25/24

CPC分类号： A61K31/57 ,  G01N33/6896 ,  G01N33/94 ,  G01N2800/304 ,  Y10T436/200833

摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

摘要翻译： 提供了改善受试者神经精神障碍症状的方法。 还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉 障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法 在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法 用于改善受试者的创伤性脑损伤的症状，改善sl的方法 受试者的睡眠障碍以及用于改善受试者的认知功能的方法。 在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢​​表雄酮（DHEA），其药学上可接受的盐，其衍生物或其组合。

公开(公告)号：US20130210783A1

公开(公告)日：2013-08-15

申请号：US13600417

申请日：2012-08-31

申请人： Christine E. Marx ,  Jed E. Rose

发明人： Christine E. Marx ,  Jed E. Rose

IPC分类号： A61K31/57 ,  A61K45/06 ,  A61K31/5685

CPC分类号： A61K31/57 ,  A61K31/5685 ,  A61K45/06 ,  G01N33/6896 ,  G01N33/94 ,  G01N2800/304

摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder. Also provided are methods for ameliorating at least one symptom resulting from tobacco cessation; and for ameliorating a symptom of Alzheimer's disease or other cognitive disorder; of schizophrenia, schizoaffective disorder, or other psychotic disorder; of a depressive disorder; of bipolar disorder; of post-traumatic stress disorder or other anxiety disorder; of a pain disorder; or of traumatic brain injury. Also provided are methods for ameliorating a sleep disorder; for improving cognitive functioning; for predicting a predisposition to suicide, suicidal ideation, and/or suicidal behavior; and for ameliorating a neurodegenerative disorder. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

摘要翻译： 提供了改善神经精神障碍症状的方法。 还提供了用于改善由戒烟导致的至少一种症状的方法; 并改善阿尔茨海默病或其他认知障碍的症状; 的精神分裂症，分裂情感障碍或其他精神障碍; 的抑郁症; 双相情感障碍; 的创伤后应激障碍或其他焦虑症; 的一种疼痛障碍 或创伤性脑损伤。 还提供了改善睡眠障碍的方法; 用于改善认知功能; 预测自杀，自杀意念和/或自杀行为的倾向; 并用于改善神经变性疾病。 在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其药学上可接受的盐，其衍生物或其组合。

公开(公告)号：US20090203658A1

公开(公告)日：2009-08-13

申请号：US12404886

申请日：2009-03-16

申请人： Christine E. Marx ,  Jed E. Rose

发明人： Christine E. Marx ,  Jed E. Rose

IPC分类号： A61K31/57 ,  A61P25/00

CPC分类号： A61K31/57 ,  A61K31/5685 ,  A61K45/06 ,  G01N33/6896 ,  G01N33/94 ,  G01N2800/304

摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

摘要翻译： 提供了改善受试者神经精神障碍症状的方法。 还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉 障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法 在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法 用于改善受试者的创伤性脑损伤的症状，改善sl的方法 受试者的睡眠障碍以及用于改善受试者的认知功能的方法。 在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢​​表雄酮（DHEA），孕酮（PROG），其前体，其代谢物， 其可接受的盐，其衍生物或其组合。

公开(公告)号：US20120142645A1

公开(公告)日：2012-06-07

申请号：US13254074

申请日：2010-03-17

申请人： Christine E. Marx

发明人： Christine E. Marx

IPC分类号： A61K31/56 ,  A61P7/00 ,  A61P3/06 ,  A61K31/566

CPC分类号： A61K31/57 ,  A61K31/5685 ,  A61K45/06 ,  A61K2300/00

摘要： Methods for ameliorating a symptom associated with hypercholesterolemia, hyperlipidemia, or both in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof. Also provided are methods for ameliorating at least one symptom resulting from undesirable cholesterol biosynthesis in a subject and methods for lowering cholesterol, low density lipoprotein, or both in the serum of a subject.

摘要翻译： 用于改善与高胆固醇血症，高脂血症或两者在受试者中相关的症状的方法。 在一些实施方案中，所述方法包括向有需要的受试者施用有效量的组合物，所述组合物包含孕烯雌酚（PG），异哌可酮（ALLO），脱氢​​表雄酮（DHEA），孕酮（PROG），其前体，其代谢物，药学上可接受的盐 其衍生物，或其组合。 还提供了用于改善受试者中不希望的胆固醇生物合成所产生的至少一种症状的方法和用于降低受试者血清中胆固醇，低密度脂蛋白或二者的方法。