公开(公告)号：US20110059855A1

公开(公告)日：2011-03-10

申请号：US12866671

申请日：2009-02-09

申请人： Christine Petit ,  Mark Lathrop ,  Anne Aubois ,  Christian Kubisch ,  Dominique Weil ,  Valerie Franco-Vidal ,  Arnaud Coez ,  Jose-Alain Sahel

发明人： Christine Petit ,  Mark Lathrop ,  Anne Aubois ,  Christian Kubisch ,  Dominique Weil ,  Valerie Franco-Vidal ,  Arnaud Coez ,  Jose-Alain Sahel

IPC分类号： C40B30/04 ,  C07H21/04 ,  C07K14/575

CPC分类号： C07K14/5759

摘要： The present invention relates to mutations located within the gene coding for adiponectin, said mutations being associated with presbycusis. The present invention further relates to adiponectin polynucleotides comprising such mutations, to adiponectin polypeptides encoded by such polynucleotides, and to methods of diagnosing and/or treating presbycusis using adiponectin polynucleotides, adiponectin polypeptides and/or ADIPOR2 polypeptides.

摘要翻译： 本发明涉及位于编码脂联素的基因内的突变，所述突变与老年性耳聋相关。 本发明进一步涉及包含这种突变的脂连蛋白多核苷酸，由这样的多核苷酸编码的脂连蛋白多肽，以及使用脂联素多核苷酸，脂联素多肽和/或ADIPOR2多肽诊断和/或治疗老年性耳聋的方法。

公开(公告)号：US3930531A

公开(公告)日：1976-01-06

申请号：US474101

申请日：1974-05-28

申请人： Josef Frehser ,  Christian Kubisch ,  Karl Swoboda

发明人： Josef Frehser ,  Christian Kubisch ,  Karl Swoboda

IPC分类号： B22D23/10 ,  C22B9/18 ,  C22B9/187 ,  C22C1/02 ,  B22D27/02

CPC分类号： C22B9/18 ,  B22D23/10

摘要： Ingots of high-melting ferroalloys and metal alloys with good forming properties are obtained by melting a consumable electrode in a slag bath in an ingot mold while cooling the ingot mold and providing a high pressure gas inert to the slag above the slag bath. The apparatus is a trisectional pressure chamber including an ingot mold which may be surrounded by a pressure container, a bell-type distributing device surrounding and extending above the mold, a cap for the distributing device through which a guide rod for a consumable electrode is introduced into the mold and a gland mounted in the cap for sealing the pressure chamber.

摘要翻译： 通过在铸锭模具中的熔渣中熔化消耗性电极，同时冷却铸锭模具并提供对炉渣上方的炉渣惰性的高压气体，获得具有良好成形性能的高熔点铁合金和金属合金锭。 该装置是包括可以由压力容器围绕的铸锭模具，围绕并在模具上方延伸的钟形分配装置的三体压力室，用于消耗电极的导杆通过该帽引导 进入模具和安装在盖中的压盖以密封压力室。