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公开(公告)号：US07582771B2
公开(公告)日：2009-09-01
申请号：US10930534
申请日：2004-08-31
申请人： Christoph M. Dehnhardt , Sreenivasulu Megati , Ronald S. Michalak , Panolil Raveendranath , Jianxin Ren , Charles C. Wu , Yangzhong Wu
发明人： Christoph M. Dehnhardt , Sreenivasulu Megati , Ronald S. Michalak , Panolil Raveendranath , Jianxin Ren , Charles C. Wu , Yangzhong Wu
IPC分类号： C07D209/10 , C07D209/14
CPC分类号： C07D209/14
摘要： A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)—(C1C6alkyl), and NO2. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).
摘要翻译： 制备式（I）的化合物的方法，其中Ac表示乙酸酯; X表示O或CH2; Y表示C1-C6烷基; 和Z选自H，卤素，CN，CHO，CF 3，OCF 3，OH，C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6硫代烷基，NH 2，N（C 1 -C 6烷基）2，NH（C 1 -C 6烷基 ），NC（O） - （C 1 -C 6烷基）和NO 2。 在其工艺中，将式（II）化合物与肼反应以形成伯烷基胺，然后将伯烷基胺与乙酸酐反应，生成式（I）化合物。
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公开(公告)号：US07342119B2
公开(公告)日：2008-03-11
申请号：US10948004
申请日：2004-09-23
IPC分类号： C07D43/02
CPC分类号： C07D209/48 , C07D209/18
摘要： A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
摘要翻译： 一种制备取代的吲哚化合物的方法，包括以下步骤：使化合物在非质子极性溶剂中在催化剂存在下反应形成中间体化合物，其中Ph和X如本文所定义; 然后在催化剂存在下，在溶剂中加热该中间体化合物，形成取代的吲哚化合物。本发明还包括通过该方法形成的化合物。
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公开(公告)号：US20080177085A1
公开(公告)日：2008-07-24
申请号：US12041988
申请日：2008-03-04
IPC分类号： C07D209/20
CPC分类号： C07D209/48 , C07D209/18
摘要： A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
摘要翻译： 一种制备取代的吲哚化合物的方法，包括以下步骤：使化合物在非质子极性溶剂中在催化剂存在下反应形成中间体化合物，其中Ph和X如本文所定义; 然后在催化剂存在下，在溶剂中加热该中间体化合物，形成取代的吲哚化合物。本发明还包括通过该方法形成的化合物。
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